UK-based Celleron Therapeutics has entered an exclusive licensing agreement with Roche for global rights to the clinical development, manufacturing and commercialisation of cancer drug, emactuzumab.

The deal is part of Celleron’s focus on drug development for cancer patients.

Emactuzumab is an experimental monoclonal antibody that targets and decreases macrophages in the tumor tissue.

Tumour-associated macrophages (TAMs) are present in the tumour microenvironment of several tumour types. These macrophages are known to support tumorigenesis via the suppression of the local immune system and promoting tumour cells growth.

Emactuzumab is designed to selectively act on TAMs by attaching to the colony-stimulating factor-1 receptor (CSF-1R) on the cell surface and inhibiting its activation by CSF-1.

The drug demonstrated favourable safety, as well as encouraging efficacy in patients with diffuse tenosynovial giant cell tumour (TGCT), which is a rare disease that develops due to the proliferation of macrophages in the joint and tendon sheath’s synovial tissue.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

Celleron Therapeutics CEO Nick La Thangue said: “Celleron’s commitment to developing transformative and novel therapies will ultimately allow emactuzumab to be brought to patients suffering from TGCT, which remains a very debilitating disease with limited clinical options.”

In 2018, Roche and its subsidiary Genentech withdrew the further study of emactuzumab after the combination of the drug with checkpoint inhibitor Tecentriq failed to show expected results in solid tumours.

Roche now offloaded the drug to Celleron for an undisclosed amount.

Celleron Therapeutics is engaged in the development of a clinical and pre-clinical pipeline of precision therapies for cancer. Its pipeline includes a dual mechanism HDAC inhibitor CXD101 and topoisomerase inhibitor CXD201.

The company has a global licence collaboration with AstraZeneca for CXD101 and is working to launch new trials in China.