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June 3, 2021

Centivax partners with US NMRC to study Covid-19 antibody

The antibody is engineered to neutralise the Covid-19 mutated variants and to allow injectable dosing in a non-hospital setting.

Centivax has signed a strategic collaboration with the US Naval Medical Research Center (NMRC) to conduct Phase I clinical development of its SARS-CoV-2 antibody, Centi-B9.

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Centi-B9 is designed as a broad-spectrum therapeutic and prophylactic for administration through injections. It is also expected to act as an adjunct to vaccines to ensure broad protection.

The antibody is engineered to neutralise the emergent Covid-19 mutated variants and showed broad-spectrum reactivity against 99.5% of all variants in the US.

It also demonstrated reactivity against more than 98% of Covid-19 variants seen worldwide which includes UK B.1.1.7, South African B.1.351, Brazilian P.1, New York B.1.526 and California B.1.429 strains.

Bioengineered for greater stability, reduced viscosity high concentration (250mg/ml) delivery, the antibody facilitates a prophylactic or therapeutic dose that can be administrated in a non-hospital setting via a single injection.

In addition, Centi-B9 was engineered using Xencor Xtend technology for improved safety and half-life.

Centivax CEO Dr David Gangemi said: “Our highly concentrated, thermostable, neutralising antibody fits the needs of the Navy, and Dod in general, in that it can be administered intramuscularly to warfighters in cramped quarters or austere environments to boost and extend protection already afforded by vaccination.

“Our antibody is highly effective against over 98% of the currently circulating variants and is a good fit for use in prolonged deployments when prophylaxis and/or post-exposure treatment is needed.”

As part of the collaboration, Centivax and NMRC will each provide a principal investigator for the clinical study.

NMRC will hold the Phase I clinical trial centre for intramuscular and subcutaneous administration of Centi-B9 and offer protocol development and medical management support.

Furthermore, the Henry Jackson Foundation is offering $4.2m non-dilutive funding for the trial.

The Phase I trial, which will validate Centi-B9’s safety and pharmacokinetics in healthy subjects, is anticipated to start next month.

These Phase I studies will facilitate a Phase II/III adaptive trial later this year.

The Phase II/III trial will analyse the antibody’s efficacy in various patient populations, such as hospitalised Covid-19 patients, pre-hospitalised individuals with the infection, post-exposure prophylaxis as well as pre-exposure prophylaxis.

Centivax intends to submit an application to obtain Emergency Use Authorization (EUA) during the interim analysis of the trial.

Related Companies

Free Whitepaper
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What is the impact of China’s Zero-COVID lockdowns on economic activity, consumer goods and the foodservice industry?

While wanting to protect the country from being overwhelmed by Omicron, China’s adherence to a Zero-COVID policy is resulting in a significant economic downturn. COVID outbreaks in Shanghai, Beijing and many other Chinese cities will impact 2022’s economic growth as consumers and businesses experience rolling lockdowns, leading to a slowdown in domestic and international supply chains. China’s Zero-COVID policy is having a demonstrable impact on consumer-facing industries. Access GlobalData’s new whitepaper, China in 2022: the impact of China’s Zero-COVID lockdowns on economic activity, consumer goods and the foodservice industry, to examine the current situation in Shanghai and other cities in China, to better understand the worst-affected industry sectors, foodservice in particular, and to explore potential growth opportunities as China recovers. The white paper covers:
  • Which multinational companies have been affected?
  • What is the effect of lockdowns on foodservice?
  • What is the effect of lockdowns on Chinese ports?
  • Spotlight on Shanghai: what is the situation there?
  • How have Chinese consumers reacted?
  • How might the Chinese government react?
  • What are the potential growth opportunities?
by GlobalData
Enter your details here to receive your free Whitepaper.

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