Biotechnology firm Codagenix has partnered with vaccine manufacturer Serum Institute of India to work together for the development of a vaccine for the new coronavirus.
The partners intend to develop a live-attenuated vaccine, which can induce an immune response to different antigens of the virus and enables scale for mass production, among other benefits.
Viral deoptimisation quickly synthesises live-attenuated vaccines. The company only requires information about the viral genome’s digital sequence to generate vaccine candidates.
For the new coronavirus, the company used its deoptimisation technology and designed several nCoV vaccine candidate genomes. The next step is to grow and conduct in-vivo tests of vaccine viruses before proceeding to clinical trials.
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Serum Institute of India will contribute to the partnership by scaling the vaccine manufacturing.
Codagenix CEO J Robert Coleman said: “With the Serum Institute’s financial and technical support, we will be able to push a coronavirus vaccine into the clinic on an extremely rapid timeline.
“Live-attenuated vaccines like the ones developed by Codagenix are ideally suited to outbreak scenarios as they scale rapidly and generally require only modest amounts of active ingredient for each immunisation, as compared to inactivated and subunit vaccines.”
The partners have adopted an accelerated development pathway to make the vaccine available rapidly.
Serum Institute CEO Dr Adar Poonwalla said: “We are very excited for this new partnership with Codagenix and we hope that we can establish a platform dealing with new infectious diseases and outbreaks beginning with the coronavirus epidemic.”
Codagenix is among the many companies and research organisations that have initiated efforts to develop a vaccine and effective treatments for the new coronavirus that emerged in China.