Every Cure has received a three-year $48.3m contract from the US Advanced Research Projects Agency for Health (ARPA-H), marking a significant federal investment in drug repurposing.

The funding will support the development of an artificial intelligence (AI)-powered platform, ML/AI-enabled Therapeutic Repurposing In eXtended uses (MATRIX) to enhance the potential of existing therapies to treat a broader range of diseases.

Every Cure plans to leverage the ARPA-H funding to create an open-source drug repurposing database and build a portal for contributions from researchers, physicians and patients.

The company also intends to publicly launch predictive efficacy scores for all therapies against all diseases and choose drugs to address neglected ailments.

Traditional drug discovery and repurposing typically focus on one disease or drug, limiting the scope of potentially life-saving treatments.

Every Cure’s approach will analyse a range of drugs and diseases simultaneously, quantifying the strength of links to identify promising new treatments.

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The MATRIX project builds on previous work by the National Center for Advancing Translational Sciences (NCATS) Biomedical Data Translator Program.

Last year, Every Cure collaborated with NCATS-funded investigator David Koslicki at Penn State University, and other Translator Program members to create pilot rankings for all 3,000 drugs approved by the FDA for all human diseases.

By using new AI techniques to assess worldwide biomedical knowledge, the company aims to detect 100 potential therapy opportunities over the five years to 2028. It plans to progress 25 of them into further research, including studies.

Early promising leads include arginine to treat sickle cell disease, folinic acid for autism spectrum disorder and bosutinib for amyotrophic lateral sclerosis.

The latest development comes after Every Cure secured funding from the Chan Zuckerberg Initiative, the Elevate Prize Foundation, Flagship Pioneering and Lyda Hill Philanthropies.

Every Cure co-founder and CEO Grant Mitchell stated: “Society’s greatest life-saving resource is the trove of medicines we already have. Leveraging a systematic, disease-agnostic approach for drug repurposing enables us to rapidly unlock new diseases they can treat and confirm the validity of AI discoveries in patients.

“We’re excited to make our research tools available to the public, advancing data-driven discovery and offering hope to patients worldwide.”