View all newsletters
Receive our newsletter - data, insights and analysis delivered to you
  1. News
November 14, 2018

Genomic profiling offers hope for rare cancer treatments

A clinical trial led by Walter and Eliza Hall Institute of Medical Research in Australia has demonstrated that genomic profiling could help match rare cancer patients with appropriate treatments.

A clinical trial led by Walter and Eliza Hall Institute of Medical Research in Australia has demonstrated that genomic profiling could help match rare cancer patients with appropriate treatments.

Conducted at four sites across Australia, the patient-driven NOMINATOR trial assessed if genomic sequencing of rare cancers can enable better diagnosis and treatment.

The trial investigators sequenced a panel of genomic markers in cancers to identify molecular features or mutations that can be targeted with treatments currently available for other cancer types with similar characteristics.

The pilot study included 36 patients. The study showed that genomic profiling yielded meaningful information in more than 50% of the participants, which influenced diagnosis and treatment.

NOMINATOR has been designed as a two-year study and is set to enrol 100 rare cancer patients with few standard treatment options.

“Genomic profiling provided meaningful information that influenced diagnosis and treatment in around half of the participants.”

Walter and Eliza Hall Institute researcher Clare Scott said: “Australians in this trial came to us after they had exhausted all their options. Using genomic profiling we were able to uncover new information that gave many patients new treatment options – and ultimately, new hope.

“Genomic profiling provided meaningful information that influenced diagnosis and treatment in around half of the participants. 20% of those tested got a new treatment plan as a result and 6% of participants were given a new diagnosis.”

A cancer type is considered to be rare if fewer than six out of 100,000 people are affected per year.

In Australia, rare cancers constitute more than 20% of cancer diagnoses and are said to be collectively responsible for more cancer deaths than any single cancer type.

The researchers believe that this type of cancer requires better treatment options, and these early trial results could be a step forward to meet the needs.

Clinical Oncology Society of Australia president Phyllis Butow said: “Around 52,000 Australians are diagnosed with rare or less common cancers each year. Those directly affected by the disease helped call for and fund this research, so it’s great to see these initial promising results being presented to cancer experts from across the country.”

Related Companies

NEWSLETTER Sign up Tick the boxes of the newsletters you would like to receive. A weekly roundup of the latest news and analysis, sent every Friday. The pharmaceutical industry's most comprehensive news and information delivered every month.
I consent to GlobalData UK Limited collecting my details provided via this form in accordance with the Privacy Policy
SUBSCRIBED

THANK YOU

Thank you for subscribing to Pharmaceutical Technology