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May 28, 2020updated 02 Aug 2022 2:07pm

Israeli scientists say Gaucher’s disease drugs may help treat Covid-19

Scientists from the Israeli Institute for Biological Research (IIBR) have claimed that analogues of two drugs used for the treatment of Gaucher’s disease could be effective against Covid-19.

Scientists from the Israeli Institute for Biological Research (IIBR) claim that analogues of two drugs used for the treatment of Gaucher’s disease could be effective against Covid-19.

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A study performed by IIBR, run by the country’s Defense Ministry, shows derivatives of Cerdelga and venglustat can act as an antiviral therapeutic against SARS-CoV-2, the novel coronavirus that causes Covid-19.

Cerdelga is a US Food and Drug Administration (FDA)-approved drug, while venglustat is currently undergoing Phase III clinical trials. Both potential Covid-19 drugs are specific inhibitors of GlucosylCeramide synthase (GCS).

According to the Israeli study findings, published in bioRxiv preprint website, the combination of these drugs led to a significant decrease in the replication capacity of SARS-CoV-2.

Researchers claim that the reduction in viral replication prevents further cell damage after infection; they carried out the study in cell culture before testing the drugs on animals.

In their publication, the researchers said: “Infection with SARS-CoV-2 reduced cell viability to 40% in the untreated cell. However, when treated with Cerdelga and venglustat, cell viability was increased to between 75% and 100%, demonstrating that they “have an antiviral effect on the SARS-CoV-2 clinical isolate in vitro.”

Both drugs were also effective against Neuroinvasive Sindbis virus (SVNI), West Nile virus and Influenza A virus.

Commenting on the research, the Defense Ministry said that the results indicate the drugs’ potential to treat different viral diseases, including future outbreaks of new viruses, if they secure clinical approval, reported TimesNowNews.

Last month, Israel Prime Minister Benjamin Netanyahu said that IIBR has made ‘significant’ progress in creating a Covid-19 vaccine prototype and preparations are underway for animal testing.

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What is the impact of China’s Zero-COVID lockdowns on economic activity, consumer goods and the foodservice industry?

While wanting to protect the country from being overwhelmed by Omicron, China’s adherence to a Zero-COVID policy is resulting in a significant economic downturn. COVID outbreaks in Shanghai, Beijing and many other Chinese cities will impact 2022’s economic growth as consumers and businesses experience rolling lockdowns, leading to a slowdown in domestic and international supply chains. China’s Zero-COVID policy is having a demonstrable impact on consumer-facing industries. Access GlobalData’s new whitepaper, China in 2022: the impact of China’s Zero-COVID lockdowns on economic activity, consumer goods and the foodservice industry, to examine the current situation in Shanghai and other cities in China, to better understand the worst-affected industry sectors, foodservice in particular, and to explore potential growth opportunities as China recovers. The white paper covers:
  • Which multinational companies have been affected?
  • What is the effect of lockdowns on foodservice?
  • What is the effect of lockdowns on Chinese ports?
  • Spotlight on Shanghai: what is the situation there?
  • How have Chinese consumers reacted?
  • How might the Chinese government react?
  • What are the potential growth opportunities?
by GlobalData
Enter your details here to receive your free Whitepaper.

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