Karuna Therapeutics has entered an exclusive licence agreement with Goldfinch Bio for investigational transient receptor potential canonical 4 and 5 (TRPC4/5) channel candidates.
Karuna signed the deal with GFB, the assignee of the Goldfinch Bio assignment estate.
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Under the deal, Karuna will have an exclusive worldwide licence for the development, manufacturing, and commercialisation of multiple Goldfinch Bio’s TRPC4/5 candidates, including GFB-887, the lead clinical-stage candidate.
The company plans to assess these product candidates as potential treatments for many psychiatric and neurological conditions.
It intends to evaluate GFB-887 to treat mood and anxiety disorders and expects to share details regarding the development in the second half of the year.
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Goldfinch Bio’s assignment estate will receive an upfront payment of $15m and is eligible for milestone payments of up to $520m for each licensed TRPC4/5 candidate, from which $410m relates to regulatory approval and commercial sales milestones.
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By GlobalDataAdditionally, the company will receive a royalty on net sales of each licensed product.
Karuna Therapeutics research & development president and chief scientific officer Steve Paul said: “We are incredibly excited to expand and diversify our development efforts and are encouraged about the potential of TRPC4/5 inhibitors to treat both mood and anxiety disorders based on pre-clinical and clinical data demonstrating anxiolytic and antidepressant properties of these inhibitors.
“Our lead candidate in the TRPC4/5 programme, GFB-887, has already demonstrated a compelling safety profile in non-clinical and clinical studies.
“We are fortunate to have found as advanced a clinical-stage drug candidate directed against these important CNS targets and we will now study GFB-887 in various mood and anxiety disorders where there remains a significant unmet medical need for mechanistically novel medicines.”
In preclinical models of mood and anxiety disorders, GFB-887 showed compelling benefits.
To advance the TRPC4/5 candidate, Karuna will use its expertise in developing therapies for psychiatric disorders.
