Lead Pharma has signed a collaboration and licence agreement with Roche for the development of oral small molecules to treat a broad range of immune-mediated diseases.

Immune-mediated disorders include joint diseases such as rheumatoid arthritis; skin diseases, including psoriasis and atopic dermatitis; as well as inflammatory bowel diseases.

According to the deal, Lead Pharma will get a €10m upfront payment and be eligible for research funding and pre-clinical milestone payments.

Total potential payments, including research, development, regulatory and sales milestones, may amount to €260m, in addition to royalties on worldwide sales.

The companies will jointly work in research activities up to the selection of a pre-clinical candidate. Later on, Roche will handle further development and global commercialisation.

The R&D partnership builds on Lead Pharma’s expertise in the discovery, design and optimisation of small-molecule treatments.

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Lead Pharma CEO Frans van den Berg said: “Our ambition is to develop life-changing treatments for patients. We are delighted to team up with Roche to pursue this goal.

“Partnering is a key element of our strategy, this collaboration is yet another validation of the value of Lead Pharma’s innovation power.”

This is the second project Lead Pharma has partnered with a major pharma company under its Discover, Design and Deliver platform.

Roche Pharma Partnering global head James Sabry said: “We are committed to advancing innovative science and transformative medicines for people affected by different immune-mediated diseases.

“We are looking forward to further building on our expertise in this field and collaborating with Lead Pharma, aiming to make a difference for those patients.”

In 2015, Lead Pharma partnered with Sanofi to develop treatments for autoimmune disease.