Clinical-stage biotechnology firm LyGenesis has formed a joint research collaboration with Imagine Pharma to develop new cell therapies for type 1 diabetes (T1D).
The companies will develop new cell therapies for patients with T1D, using LyGenesis’ allogeneic cell therapy platform and Imagine Pharma’s Type 1 Diabetes Activated Islet Progenitor Cells (T1D AIPCs).
The partnership will facilitate the quick development of a preclinical proof of concept programme for the treatment of T1D using Imagine Pharma’s AIPCs as the cell source, together with LyGenesis’ use of the lymph node as a bioreactor capable of growing a functioning ectopic pancreas.
LyGenesis CEO and co-founder Dr Michael Hufford said: “We’re thrilled to announce our collaboration with Imagine Pharma to utilise their unique cell-source with our use of endoscopic ultrasound engraftment of cell therapies into the lymph node for the treatment of diabetes.
“With our lead cell therapy already in clinic [clinical trials] for the treatment of end-stage liver disease, Imagine Pharma’s AIPCs hold remarkable promise to rapidly advance our pipeline of therapies.”
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According to the company, around 1.45 million people in the US are affected with T1D, with nearly 64,000 new diagnoses per year.
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By GlobalDataImagine Pharma founder, chief marketing officer and co-CEO Ngoc Thai said: “We envision that our novel cell population of AIPCs, used in conjunction with LyGenesis’ cell therapy platform, holds breakthrough potential for the treatment of type 1 diabetes.”
In June 2022, the company discovered T1D AIPCs, a critical component to treat T1D through autologous cell transplantation.
Cell & Gene Therapy coverage on Pharmaceutical Technology is supported by Cytiva.
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