The US Food and Drug Administration (FDA) has approved Neurocrine Biosciences’ Ingrezza (valbenazine) capsules to treat adults with tardive dyskinesia (TD).

Ingrezza is a selective vesicular monoamine transporter 2 (VMAT2) inhibitor and clinical studies have shown that it provides rapid improvement in TD signs and symptoms.

TD is characterised by uncontrollable, abnormal and repetitive movements of the trunk, extremities and / or face and is caused by treatments such as antipsychotics and other medications that block dopamine receptors in the brain.

Its symptoms can be severe and are often persistent and irreversible.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

Neurocrine Biosciences CEO Kevin Gorman said: “The approval of Ingrezza represents a turning point for these patients and their care partners, offering a meaningful treatment where before there was little hope.

“For the past 20 years, Neurocrine has been devoted to developing treatments for difficult to manage conditions in underserved patient populations.”

“The approval of Ingrezza represents a turning point for these patients and their care partners, offering a meaningful treatment where before there was little hope.”

In clinical trials of Ingrezza, no worsening in safety scale scores for depression, suicidal ideation or behaviours was observed.

The indication has been studied in more than 1,000 individuals and more than 20 clinical trials.

Neurocrine Biosciences chief medical officer Christopher O’Brien said: “The FDA’s approval of Ingrezza represents the culmination of over ten years of dedicated effort from the Neurocrine research and development teams.

“Neurocrine would like to thank the many clinical investigators and TD patients who participated in our clinical trials.”


Image: Tardive dyskinesia is believed to involve the neurotransmitter dopamine. Photo: courtesy of Sbrools.