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March 31, 2020

Noveome studies anti-inflammatory drug ST266 in Covid-19

Next generation biologics company Noveome Biotherapeutics will evaluate its lead programme ST266 as a potential treatment of severe cytokine storm response associated with Covid-19.

By Allie Nawrat

Next generation biologics company Noveome Biotherapeutics will evaluate its lead programme ST266 as a potential treatment of severe cytokine storm response associated with Covid-19.

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ST266, which was initially developed by Noveome for ophthalmology indications, is a first-of-its-kind cell-free platform biologic drug, composed of hundreds of anti-inflammatory proteins, known as the secretome. The proteins are collected from donated, full term caesarean-sectioned placentas, which are normally discarded after birth.

In clinical trials to date, ST266 has shown to be safe and effective at reducing inflammatory response in humans. The drug has been shown to have neuroprotective and cell restoration properties.

Noveome is hoping to agree an expedited investigational new drug approval with the US Food and Drug Administration (FDA), so that clinical trials can begin in the fourth quarter of 2020.

If approved, this drug could mitigate issues with hospitals experiencing shortages of ventilators.

Noveome founder, chairman and CEO William Golden said: “As we continue to learn from the emerging data on Covid-19, it is clear that mitigating the cytokine storm associated with severe cases is crucial to treating this condition and improving patient outcomes.

“Based on our positive preclinical and clinical data, we believe that ST266 has the potential to reduce the severe inflammatory response in patients with Covid-19 and we have initiated our efforts to evaluate ST266 in these patients.”

A member of the company’s board of directors and Massachusetts Institute of Technology professor Robert Langer added: “This ongoing pandemic has mobilised an unprecedented and rapid response by the biopharmaceutical industry to identify possible new therapeutic interventions and Noveome’s science has a compelling rationale to add to these efforts.

“The body’s response to severe infection in vulnerable Covid-19 patients is a dangerous and increasingly fatal inflammatory overreaction due to a cytokine storm.

“ST266 has the potential to control this reaction to prevent deaths associated with Covid-19.”

Related Companies

Free Whitepaper
img

What is the impact of China’s Zero-COVID lockdowns on economic activity, consumer goods and the foodservice industry?

While wanting to protect the country from being overwhelmed by Omicron, China’s adherence to a Zero-COVID policy is resulting in a significant economic downturn. COVID outbreaks in Shanghai, Beijing and many other Chinese cities will impact 2022’s economic growth as consumers and businesses experience rolling lockdowns, leading to a slowdown in domestic and international supply chains. China’s Zero-COVID policy is having a demonstrable impact on consumer-facing industries. Access GlobalData’s new whitepaper, China in 2022: the impact of China’s Zero-COVID lockdowns on economic activity, consumer goods and the foodservice industry, to examine the current situation in Shanghai and other cities in China, to better understand the worst-affected industry sectors, foodservice in particular, and to explore potential growth opportunities as China recovers. The white paper covers:
  • Which multinational companies have been affected?
  • What is the effect of lockdowns on foodservice?
  • What is the effect of lockdowns on Chinese ports?
  • Spotlight on Shanghai: what is the situation there?
  • How have Chinese consumers reacted?
  • How might the Chinese government react?
  • What are the potential growth opportunities?
by GlobalData
Enter your details here to receive your free Whitepaper.

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