OSE’s Covid-19 vaccine shows promise in preclinical studies

OSE Immunotherapeutics has reported positive data from preclinical and human ex-vivo studies of its Covid-19 vaccine candidate, named CoVepiT.

Share

OSE Immunotherapeutics has reported positive data from preclinical and human ex-vivo studies of its Covid-19 vaccine candidate, CoVepiT.

The company published the findings online on BioRxiv.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

Based on optimised peptides improved with artificial intelligence algorithms, CoVepiT elicits a lasting sentinel T lymphocyte immune response against Covid-19.

It is a neoepitope vaccine meant for prophylactic protection against the disease, generated using OSE’s Memopi technology.

According to preclinical data, the candidate led to strong trigger of memory CD8 T lymphocytes against various SARS-CoV-2 proteins in vaccinated humanised mice.

In humanised mouse model studies, CoVepiT vaccination resulted in an encouraging phenotype of Tissue-resident memory T-cells (Trm).

These Trm cells protect barrier tissues such as the respiratory tract and the lung, and remove infected cells prior to significant virus replication, noted the company.

OSE added that patients with asymptomatic, moderate and severe Covid-19 showed strong memory T-cell responses against the company’s multi-target peptides.

OSE Immunotherapeutics chief scientific officer Nicolas Poirier said: “The CoVepiT programme is based on a clinically-validated technology now shown to induce tissue-resident memory T lymphocytes (Trm) sentinel response against multiple parts of SARS-CoV-2, suggesting it provides a long-term protective immunity, as opposed to transient protection provided by neutralising antibodies.

“In addition, this vaccine is designed to anticipate ongoing recurrent virus mutation and evolution, further adding to its long-term protective potential. T-cell epitopes were also selected based on the natural immunity observed against our peptides in convalescent Covid-19 patients.”

Funding from Nantes Metropole supported the preclinical programme of CoVepiT.

Based on these positive findings, OSE intends to launch a Phase I clinical trial by the end of this year or early next year to assess the vaccine candidate’s efficacy in humans.

More Relevant

close

Sign up to the newsletter: In Brief

Your corporate email address *
First name *
Last name *
Company name *
Job title *
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

Thank you for subscribing

View all newsletters from across the GlobalData Media network.

close