UK-based Oxford BioMedica has signed a new collaboration and licence agreement with Bioverativ for the development and manufacture of lentiviral vectors to treat haemophilia.

The agreement will see an upfront payment of $5m by Bioverativ to Oxford BioMedica, which is also eligible for an additional $100m in different milestone-based payments.

Oxford BioMedica will also receive net sales royalties on Bioverativ’s lentiviral vector haemophilia products.

Oxford BioMedica CEO John Dawson said: “Bioverativ’s investment in haemophilia gene therapy underlines the potential of lentiviral vectors for use for in-vivo gene therapy.

“This new deal, potentially worth in excess of $100m, demonstrates Oxford BioMedica’s strategy of building multiple partnerships with leaders in their therapeutic categories and will support the group’s continued growth.”

“Bioverativ’s investment in haemophilia gene therapy underlines the potential of lentiviral vectors for use for in vivo gene therapy.”

The agreement also involves a licence to leverage Oxford BioMedica’s LentiVector Enabled technology, as well as access to the firm’s industrial-scale manufacturing technology.

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Designed as an advanced lentiviral-based gene delivery system, the LentiVector platform has applications in various therapeutic areas. It can genetically modify dividing and non-dividing cells, and insert genes into non-dividing cells.

The platform also acts as a research tool with uses in stem cell manipulation, transgenesis, somatic disease models, target validation and gene discovery.

Bioverativ will sponsor the activities associated with the process development and scale-up of its lentiviral vector haemophilia products at Oxford BioMedica.

In addition, the agreement includes an option to negotiate a clinical supply agreement for GMP manufacturing of these products at the company.