Sen-Jam has collaborated with Duke-NUS Medical School in Singapore to commence a Phase II clinical trial of the investigational therapy, SJP-002C, for the treatment of Covid-19 in Nepal.
Discovered by Sen-Jam Clinical Development head Jacqueline Iversen, SJP-002C is a combination of a specific non-steroidal anti-inflammatory drug (NSAID) and a specific antihistamine that can potentially disrupt runaway inflammation.
The investigational drug combination, with demonstrated anti-viral properties, could pre-emptively halt Covid-19 progression to the severe acute respiratory syndrome (SARS) stage, Sen-Jam, a life-science start-up, noted.
Inflammation caused by SARS affects the lungs and other organs and could cause long-lasting health issues and death.
The presently available therapies for SARS inflammation are corticosteroid drugs such as dexamethasone.
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By GlobalDataIf used before the SARS appearance, these drugs were demonstrated to offer counter-productive impact and could suppress the adaptive immune response of the body.
Intended to be used before Covid-19 patients progress to the SARS stage, SJP-002C can potentially prevent dangerous disease development, the company added.
Iversen said: “SJP-002C is a potent anti-inflammatory with minimal side effects that can be administered on day one.
“We believe SJP-002C can be used to reduce disease progression, hospitalisation and severe lung damage.”
Under a joint development agreement with Duke-NUS, the Phase II trial of the combination drug is set to start in Nepal in the coming months.
Duke-NUS Medical School researcher Ashley St. John said: “The collateral damage to the lung tissue caused by inflammation is the major obstacle to recovery from Covid-19 and so we think a targeted approach to reduce inflammation has the potential to improve health outcomes.”
Apart from the potential Covid-19 therapeutic, Iversen has also detected various other applications for small molecule combinations as treatments for several common inflammatory and pain conditions.
Sen-Jam is currently pursuing investments to advance research that could result in licensing collaborations with investors for its 24 domestic and global patents and pending patents.
