Symcel partners with Karolinska Institutet to validate calScreener in clinical antimicrobial susceptibility testing.

The collaboration will evaluate Symcel’s cell-based assay tool, calScreener, designed to measure cell metabolism in real-time.

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The technology will be assessed for its ability to test the efficacy of different antibiotic combinations against drug-resistant bacteria in sepsis patients.

Karolinska University Hospital associate professor Christian Giske will lead the research that aims to validate calScreener as a ‘reliable reference point’ for clinical microbiologists.

Giske said: “Early results from our initial tests on Symcel’s technology, carried out in our research laboratories, showed that calScreener has great promise for use in clinical laboratories and for addressing key challenges in antimicrobial susceptibility testing.”

According to Symcel, The calScreener method is well positioned for combination testing due to its total metabolic response in real-time, very high sensitivity and no limit to the number of antimicrobials that can be tested at once.

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“calScreener can aid antimicrobial stewardship as the ability to generate actual results and data on antimicrobial resistance at an early stage enables informed judgments to be made in good time.”

It can optimise monotherapies to prevent the use of sub-efficient concentrations of a compound and offers an alternative to the standard reference methods that are often slow and not suitable for multi-resistant bacteria.

Symcel CEO Jesper Ericsson said: “calScreener can aid antimicrobial stewardship as the ability to generate actual results and data on antimicrobial resistance at an early stage enables informed judgments to be made in good time on whether to switch or modify a treatment.

“We are confident that our technology will emerge as a validated and unique surrogate method that will enable clinicians to correctly determine which antibiotics really work against multi-resistant bacteria.”