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November 12, 2020

Taiho signs drug licensing deal with Lung Therapeutics in Japan

Taiho Pharmaceutical has entered into an exclusive licence agreement with Lung Therapeutics for the latter’s investigational recombinant human single-chain urokinase plasminogen activator, LTI-01, in Japan.

Taiho Pharmaceutical has entered an exclusive licence agreement with Lung Therapeutics for the latter’s investigational recombinant human single-chain urokinase plasminogen activator, LTI-01, in Japan.

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According to the deal, Taiho will gain the rights to develop and commercialise LTI-01 in the country.

Lung Tx will get an upfront payment, milestone and royalty payments depending on the product sales.

Lung Therapeutics CEO Brian Windsor said: “LTI-01 has the potential to be the first and only approved therapeutic for loculated pleural effusion patients.

“We are honoured to partner with Taiho, a Japanese pharmaceutical company with a commitment to the respiratory field, for the development and commercialisation of LTI-01 in Japan.”

Being developed by Lung Tx as a treatment for loculated pleural effusions (LPE), LTI-01 is an injectable proenzyme that improves the fibrinolytic system and destroys the fibrinous scar tissue that causes LPE.

LPE is a condition in which fluid is trapped within the pleural cavity due to fibrinous adhesions. This leads to pain, shortness of breath and even sepsis.

LTI-01 can potentially promote drainage in LPE patients by lysis of fibrinous scar tissue in the pleural cavity.

Taiho president and representative director Masayuki Kobayashi said: “We are delighted to announce this new collaboration with Lung Tx for LTI-01.

“Bringing together two companies’ expertise and strengths, we believe we can further contribute to patients’ QOL by providing a solution to an unmet medical need in the respiratory field.”

A  Phase III randomised, placebo-controlled, double-blind, dose-ranging study in patients with infected, non-draining LPE is currently being conducted in the US.

LTI-01 has received Orphan Drug Designation in the US and EU, as well as Fast Track Designation in the US.

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