In this white paper, Trevor Calkins and Nancy Coffman study the uses of parenteral-grade sucrose in...
Sucrose is a non-reducing crystalline disaccharide made up of glucose and fructose, found in many plants but extracted as ordinary sugar mainly from sugar cane and sugar beets.
Pfanstiehl brand, high-purity low endotoxin (HPLE) Sucrose is used in the biopharmaceutical industry to stabilise proteins, lipids, and carbohydrates throughout the formulation and freeze / thaw lifecycle of therapeutics.
It is also widely applied as a cryopreservative and media supplement in a variety of cell-based bioprocesses. It is preferred to trehalose in applications where solubility and/or viscosity issues are paramount.
The benefits of sucrose include but are not limited to:
- Monoclonal antibody (mAbs) stabilisation
- Media supplementation
- Antibody drug conjugate (ADC) stabilisation
- Peptide stabilisation
- Stem cell preservation
- Vaccines stabilisation
Pfanstiehl Brand Sucrose is available as USP-NF (United States Pharmacopoeia – National Formulary), EP (European Pharmacopoeia) and JP (Japanese Pharmacopoeia). Pfanstiehl also holds a US DMF for the Sucrose (S-124-2-MC) product.
In the pharmaceutical industry, products that benefit from the stabilising effects of trehalose include, but...
Pfanstiehl has announced that it will be sponsoring the 2019 Colorado Protein Stability Conference. Taking place...
Sucrose, trehalose, mannitol and maltose are four of the most commonly utilised carbohydrates for protein...