The Immunex facility at Bothell needed specially constructed water pipe systems for the supply of its exceptionally pure water. These had to be made with specialised machines.
The process development facility at Bothell was the third major facility to be built there.
The process development facility at Bothell was in use by the end of 2001.
The Bothell facility covers 50,000ft<sup>2</sup>.
The Bothell process development facility saw production gradually geared up during the course of 2001 to full capacity by the opening of 2002.
As well as the Bothell facility, Immunex is also investing in facilities in Seattle (the Helix project).
Immunex's new site facility.

Bothell is the site of a process development facility owned by the pharmaceuticals firm Immunex, which is now owned by Amgen.

The facility is designed to act as a pilot plant for new pharmaceutical products. In particular, the biotechnology company uses the pilot plant to try out genetically modified drug production.

The 50,000ft² building is the third Immunex building on the Bothell site. It is designed to be able to accommodate future expansions, although none are expected in the near future. Immunex is also investing in facilities in Seattle (the Helix project) and in West Greenwich in Rhode Island.

The Bothell pilot plant facility

The new Bothell plant has 16,500 lineal feet of high-purity stainless steel piping and 7,800 orbital welds. It was built at a cost of about $50 million and uses 2l bioreactors.

The smaller scale reduces the cost of trying out new products. However, the process facility was not intended to go through the full Food and Drug Administration (FDA) approval process, but it nevertheless underwent a closely documented construction process to meet industry standards.

Process development facility design

The process development facility uses pre-cast concrete as its main material. This accounts for around 70% of the building envelope. In addition, it is constructed with a series of coloured concrete panels.

The exterior also uses metal strips and a glazing structure. The glazing is tinted and limited on the sun facing aspects of the building in order to limit solar heating in warm weather. At the same time, the building is designed to maximise the use of natural light.

The laboratory requirements of the interior also demanded an efficient floor plan.

Process development facility construction timescale

The Bothell project was begun in late-1999. It took 14 months to complete.

The development facility saw production gradually increased throughout 2001 to full capacity by the opening of 2002.

Water supply at the Boethell process development facility

The Bothell facilities demanded a sophisticated piping system for high-purity water for injection (WFI) and deionised water (WDI). This demanded a lot of orbital welding.

Orbital welding makes the surfaces of the piping smoother, ensuring that micro-organisms do not grow and contaminate the process. The smoother welding also limits corrosion.

Process facility shutdown

The launch of the pilot plant was complicated as some old facilities needed to be shutdown to reintegrate them with the new systems. The month-long connection process created 85 utility tie-ins, which often had to be completed in a very short time to not to disrupt the plant.

The careful connection allowed the old facilities to continue to operate during the link up period.

Amgen/Immunex takeover bid

The operation of the Bothell facility is likely to be unaffected by the takeover bid announced for Immunex by Amgen in December 2001. The bid included provision for Amgen to buy out American Home Products’ 41% share of Immunex.

Lead contractors

Eichleay Engineers, Ehrlich Rominger and HDR Architects acted as architects for the facility. DPR Construction was the general contractor on the project, while Valley and McCarthy Construction carried out preliminary studies on the project before the main work began. There were also a number of other small contractors and sub-contractors involved.