22 April 2020
A US National Institutes of Health (NIH) panel has recommended against the use of hydroxychloroquine in combination with azithromycin as a Covid-19 treatment. Hydroxychloroquine, which was touted by President Donald Trump, could lead to heart issues and the combination may cause harm, said the panel.
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The US Food and Drug Administration (FDA) has granted approval for Hope Biosciences to conduct a third Covid-19 clinical trial. In the latest Phase II study, the company will investigate whether mesenchymal stem cells, which are associated with immunomodulatory and regenerative properties, could be a safe and effective therapeutic option against the novel coronavirus. The previous two studies are focused on prevention of Covid-19 infection.
SOM Biotech has completed in-vitro analysis and identified three drug candidates that can be potentially used to treat Covid-19. The three candidates, which were discovered using the company’s artificial intelligence-based screening technology, inhibit the main protease of SARS-CoV-2, the virus that causes Covid-19, in turn targeting viral replication.
OncoImmune has started a Phase III clinical trial of CD24Fc to assess the drug candidate’s ability to dampen inflammation caused by virus-induced cellar injuries in patients with Covid-19. The trial will enrol 230 patients with severe clinical symptoms at a minimum of ten medical centres across the US.
Norton Healthcare has enrolled the first participant for a Phase II clinical trial assessing low-dose selinexor, which is manufactured by Karyopharm Therapeutics, for Covid-19. Selinexor is the multiple myeloma drug, with antiviral and anti-inflammatory properties that could be effective against the novel coronavirus.
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By GlobalData
