Eli Lilly and Company has announced positive data from its Phase II study of cixutumumab in five subtypes of sarcoma, a cancer related to connective tissues.
The Phase II trial included 113 patients with advanced or metastatic soft tissue sarcoma and in the Ewing family of tumours, and demonstrated that 57% of patients taking cixutumumab experienced stable disease.
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The study was evaluated in five tiers and the overall response was reported as one partial response in the Ewing sarcoma tier, stable disease of 41% in leiomyosarcoma, 35% in synovial sarcoma, 28% in Ewing family of tumours and 24% in rhabdomyosarcoma.
The treatment-related adverse affects include hyperglycaemia, asthenia, pain and thrombocytopenia.
Cixutumumab is a monoclonal antibody that targets the insulin-like growth factor-1 receptor, which plays a major role in cancer cell proliferation, survival and resistance to therapy.
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