Durect has signed a development and commercialisation agreement with Sandoz, a division of Novartis, to develop and market Posimir (Saber-Bupivacaine) in the US.

Posimir is an investigational, locally acting, non-opioid analgesic indicated to provide up to three days of continuous pain relief following surgery.

It uses the Saber technology that consistently delivers bupivacaine to the surgical site for 72 hours.

Durect is currently conducting PERSIST, a Phase III trial in patients undergoing laparoscopic cholecystectomy (gall bladder removal) to compare its effect with bupivacaine HCl.

Posimir is a drug candidate and is yet to receive approval from the US Food and Drug Administration (FDA) or other health authorities.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

See Also:

"We believe that Posimir has the potential to become a cornerstone of multi-modal, post-operative pain management."

Durect president and CEO James Brown said: “We are delighted to collaborate with a company with the market presence and resources of Sandoz to commercialise Posimir in the US.

“We believe that Posimir has the potential to become a cornerstone of multi-modal, post-operative pain management.

“As a non-opioid local analgesic, we believe Posimir may be an important contributor to the ongoing efforts to reduce the use of opioid-based medications following surgery.”

Under the agreement, Sandoz will make an upfront payment of $20m to Durect, along with the potential for up to an additional $43m in development and regulatory milestones, as well as another $230m in sales-based milestones along with a double-digit royalty on product sales in the US.

Durect will carry out the ongoing PERSIST Phase III clinical trial for Posimir, as well as FDA interactions through approval.

The transaction is expected to be completed in the second quarter of this year, subject to completion of review under the Hart-Scott-Rodino (HSR) Antitrust Improvements Act of 1976.