A new epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) treatment may be on the horizon for Molecular Partners.
The biopharmaceutical company has numerous pipeline candidates but has yet to bring a drug to market. However, their recent co-development with AstraZeneca is a significant boost for their lead oncology candidate, MP0250. The partnership will allow Molecular Partners to trial MP0250 with AstraZeneca’s antineoplastic agent osimertinib (Tagrisso) in Phase Ib/II studies. MP0250 prevents tumor growth by inhibiting two growth factors, hepatocyte growth factor (HGF) and vascular endothelial growth factor (VEGF). Used in combination with osimertinib, an EGFR-mutated NSCLC tumor cell suppressant, it is likely to be an effective NSCLC treatment. MP0250 has also shown promise as a treatment for multiple myeloma. In January, the company announced positive preliminary safety and efficacy data for its Phase II trial with bortezomib and dexamethasone.
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Molecular Partners’ other market hopeful, Abicipar, has made positive strides as a therapy for wet age-related macular degeneration and diabetic macular edema, with Phase III efficacy results for wet age-related macular degeneration expected later this year from their collaborator, Allergan.
These trials, as well as a robust pipeline of early-stage oncology and immuno-oncology drugs, suggests Molecular Partners will likely be attracting more big-pharma deals and getting a drug to market in the coming years.
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