Type 2 diabetes (T2DM) is a chronic and progressive metabolic disorder associated with many different complications.
Patients require increasingly complex treatment regimens with many different drug types.
The demand for T2DM therapeutics has resulted in a large and competitive market landscape, with a number of drugs competing with one another for different market segments, across multiple lines of therapy.
Since the mid-2000s, a number of new drug classes have entered the market, including glucagon-like peptide-1 (GLP-1) receptor agonists, dipeptidyl peptidase 4 inhibitors, and sodium–glucose linked transporter-2 inhibitors.
These drug classes have proved to be highly commercially successful.
This has led to a diverse pipeline, with many new molecular target groups that do not exist or are poorly represented in the market.
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The strong showing of G protein-coupled receptors (GPCRs) in the pipeline is a result of the success of GLP-1 receptor agonists.
The diversity of the pipeline suggests that a new wave of therapy types may become available to T2DM patients and aid in developing new and more effective treatment regimens.
Frontier Pharma: Type 2 Diabetes Mellitus – Therapies Targeting GPCRs and Protein Kinases Dominate Pipeline, with Strong Repositioning Opportunities into Associated Areas, Including Obesity and Cardiovascular Disease
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