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  1. Gamlen Instruments
11 November 2016

Gamlen’s D Series Dynamic Powder Compaction Analyser for Advanced Tableting Research

Gamlen’s new flagship D series dynamic powder compaction analyser for advanced tableting research features dwell time control ranging from 90 milliseconds to 60 seconds.

D-series analysers are supplied with new in-die and out-of-die compaction analysis software, which generates tablet detachment and ejection data with full profiles including strain data and Heckel and Kawakita plots. An optional add-on, the tablet tensile analyser (TTA) automatically calculates tablet density and solid fraction, as well as tablet tensile fracture stress.

Managing Director of Gamlen Michael Gamlen commented "The D-series will change the way scientists characterise materials. The key element of the D series is our unique dynamic compaction analysis software, which allows researchers to characterise the elasticity and plasticity of materials at each compaction event, as well as their lubricity and punch detachment behaviour.

"This is in addition to recording, in real-time, compaction and ejection profiles of an active pharmaceutical ingredient (API), excipient, or drug formulation.

Researchers will now be able to create a database of material-specific data to support a wide variety of investigations, such as screening for compatible excipients, and enabling accelerated formulation and process development and scale-up to manufacturing."

Tablet tensile strength can be measured on a D-series instrument via an included high-sensitivity load cell, or alternatively by using the Gamlen TTA. This is a complementary stand-alone system, which measures tablet fracture stress properties in addition to out-of-die weight and thickness of a tablet produced on a D-series instrument.

The included TTA software package automatically captures all of these parameters and produces compaction triangle plots of compactibility, compressibility, and tabletability.

With a rapidly expanding product range, Gamlen Tableting has transformed its entire product line to include the Gamlen M series for small-scale manufacture of tablets under tightly controlled conditions and the R series (formerly known as the GTP-1) to support fundamental tableting research and development in a university or company environment.

Gamlen presents a study conducted by V. Penkavova1, L. Kulaviak1, M.C. Ruzicka1, M. Puncochar, and P. Zamostny on the 'Beaking of Anisotropic Rod-Saped Particles'.
The efficiency of downstream processing of active pharmaceutical ingredients (API) can depend on their particulate properties, including size and shape.
This whitepaper described a method for performing dynamic powder compaction analysis and for measuring tensile fracture strength of tablets.
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