Malvern Panalytical has announced its next batch of webinars this month.
If you are interested in attending any of these webinars, please make an enquiry using the form on this page.

Quality by Design: Principles for Pharmaceutical Method Development

The quality by design (QbD) principles outlined by Jurong find a natural home in the arena of pharmaceutical method development.

This presentation will outline what QbD is and how it works within pharmaceutical development. It will provide some examples of the fishbone diagrams that show the factors that should be considered when developing methods for laser diffraction and dynamic light scattering.

This webinar will take place on 6 September at 10:30 (GMT-5:00).

Speaker key account technical specialist Steve Ward-Smith will provide an understanding of QbD and the associated variables in two of the primary particle sizing techniques used today.
Those involved in developing methods for the development/analysis of pharmaceuticals or in transferring methods between locations or instruments should attend.

Adaptive Correlation: How to Get Better DLS Data with Less Time and Effort

In this webinar, Malvern Panalytical introduces a new dynamic light scattering (DLS) data capture process called adaptive correlation, which addresses issues to provide a more complete and accurate characterization of your sample.

While being able to measure particles of below 1nm size, DLS is preferentially sensitive to larger particles due to the sixth power relationship between particle radius and scattering intensity. This means that sample preparation typically needs to be scrupulous, especially for low scattering samples such as proteins and biological molecules.

The contribution to contaminants such as dust and aggregates can be mitigated by filtering, however this may not always be practical and constitutes a financial burden, both in terms of additional sample preparation time and consumables costs.

This webinar will take place on 11 September from 10:30 to 11:30 (GMT-5:00).

Speaker Dr Alex Malm has worked within the nanomaterials research and development (R&D) team since joining Malvern Panalytical in 2015. As part of the development team for the new Zetasizer Pro and Ultra, Alex has developed new algorithms and supported the development of electronics and optical systems, and now also acts as an intellectual property officer, helping to manage Malvern Panalytical’s patent portfolio. He has a Master of Physcics (MPhys) from the University of Manchester, where he also completed a Doctorate in Enterprise supported by Malvern. He developed light scattering techniques to characterise the structure and rheology of colloidal and polymer solutions.

Existing Zetasizer and competitor users who want to understand the benefits of adaptive correlation should attend the webinar to understand the benefits it can offer over traditional correlation approvals. You will learn how adaptive correlation works and the benefits it can offer such as faster measurements, more reliable data and less sample preparation.

Demo at your desk: Morphologi 4

This online demonstration is designed to get you up close and personal with the Morphologi 4 platform.

You will be given an insider’s look at the instrument and its accessories via Malvern Panalytical’s lab webcam and follow the measurement of typical samples using the Morphologi 4 and Morphologi 4-ID, including Morphologically-Directed Raman Spectroscopy (MDRS®).

This will introduce you to automated image analysis and the powerful Morphologi software to show you how the combination of size and shape parameters can be used to better understand your materials.

Malvern Panalytical will then look at how a dry powder sample can be dispersed using the integrated sample dispersion unit before running a quick measurement and taking you through the software features available for interpreting the results. There will also be time to ask any questions that you have about image analysis and the Morphologi 4 and Morphologi 4- ID.

This webinar will take place on 12 September from 10:30 to 11:30 (GMT-5:00)

Speaker Rob Taylor spent nearly four postgraduate years firing lasers at precious metals and discovering electrochemical and spectroscopic applications in pharmaceutical development. The following eight years was a journey into measuring properties for lead optimisation and preformulation, where Rob gained valuable knowledge about drug release from oral solid dosage forms. Here, particle size and shape are critical to controlling the performance of drugs in-vivo.

In the last year, Rob made the move to Malvern Panalytical where he is discovering the application and nuances of measuring particle morphology and how this impacts both the performance and quality of not only pharmaceutical products, but also food and advanced materials such as metal powders and building materials. As a technical specialist for the Morphologi 4 platform, Rob is keen to hear how your processes utilise particle size and shape and to share knowledge of these applications.
People who have an interest in particle size and shape such as image analysis, Raman analysis of particles, pharmaceutical product development and deformulation should attend the webinar, as well as metal powder manufacturers, those working in the food or forensics industries, and anybody that has recently sent in evaluation samples.

You will learn how the Morphologi 4 instrument and platform operates, automated powder dispersion for reproducible sample presentation, other sample presentation options, automated image capture, data processing and analysis and batch comparison.

Biophysical and Stability Characterization of Antibody-Drug Conjugates

Antibody-drug conjugates (ADC) are a rapidly growing class of oncology therapeutics wherein a potent cytotoxic drug is conjugated to the antibody molecule.

The impact of drug conjugation on the antibody’s conformation needs to be evaluated. The drug conjugation can also affect various physical properties of the antibody molecule, which in turn can affect its stability and aggregation propensity.

This presentation summarises results from Malvern Panalytical’s study on aggregation of a lysine-conjugated ADC and its unconjugated monoclonal antibodies (mAb) under accelerated heat and agitation stresses.

In addition, the company also highlights spectroscopic and DSC based analytical approaches that can be used to detect subtle differences between the ADC and mAb.

This webinar takes place on 13 September from 10:30 to 11:30 (GMT-5:00)

Speaker and guest presenter Aditya Gandhi graduated in 2010 from University of Mumbai, India, with a bachelor’s degree in Pharmacy. He then earned a master’s degree in Industrial Pharmacy from St John’s University, New York. With a keen interest in biotherapeutics, Aditya joined the pharmaceutical sciences programme at the University of Colorado in August 2013 where he works on in-depth characterisation of physical stability and aggregation of therapeutic proteins.

Anyone interested in biopharmaceuticals, especially antibody-based therapeutics, should attend the webinar to learn about the biophysical properties of ADCs, including some analytical considerations for ADCs and the impact of drug conjugation on protein aggregation.

The Benefit of Capillary Rheometry in the Fabrication of Polymer Scaffolds for Tissue Engineering

Polymers are extensively used for tissue repair and replacement in the form of implantable biomedical scaffolds. Examples include surgical meshes, cardiovascular stents, nerve conduits, and bone regeneration scaffolds and fixation devices.

Thermal processing is a common denominator in all these applications. Rather than discuss use of the rheometer to study polymer rheology, on which a large body of literature exists, the webinar will focus on the use of capillary rheometer as a tool for optimising the process parameters with a few grams of polymer before using up hundreds of grams in extruders. Capillary rheometer is indispensable in the evaluation of degradable polymers that have a tight window for processing. Malvern Panalytical has taken advantage of the temperature stability of the rheometer to assess the thermal stability of polymers, and drugs and processing aids that are incorporated into polymers.

A rheometer can also be used as a small-scale extruder to screen a large number of polymers by extruding around 100m diameter fibres to discover their mechanical and degradation behaviour. Malvern Panaslytical has also used rheology to referee the molecular weight determinations of a series of polymers.

Some examples of recent successes using the rheometer in the company’s laboratory are the optimisation of the conditions for extrusion of fibres from our tyrosine-derived polymers, extrusion of around 5mm rods for machining into bone fixation screws, evaluation polymers for 3D printing applications, and for extruding the 1.75mm diameter filaments for use with 3D printers that use fusion

This webinar will take place on 18 September from 10:30 to 11:30 (GMT-5:00)

Speaker and guest presenter Professor Sanjeeva Murthy is an associate research professor at the New Jersey Center for Biomaterials (NJCBM). He is a materials scientist with expertise in polymers, bio-materials and biological structures. His current activities at the lab include testing and characterisation of new polymers for regenerative medicine, and fabricating them into devices, scaffolds for tissue repair and replacement, biomedical implants, nerve regeneration scaffolds and drug delivery systems. A common denominator in all NJCBM’s research projects is the processing of polymers into various forms, fibres, pins and films.

Anybody using polymer extrusion processes that would like to know how capillary rheometry can be used to optimise processing conditions should attend the webinar to learn how capillary rheometry can be used to screen large numbers of polymers for stability and processing prior to larger scale extrusion, thereby saving time and money.

You will learn how capillary rheometry can be used to screen biodegradable polymers and additives for thermal stability and process-ability with just a few grams of sample.

Demo at your Desk – Epsilon 4

Optimise your processes and comply with stringent international regulations by fast and accurate elemental analysis. Suitable for any industry, Epsilon 4 is the next step in energy dispersive XRF.

Combining the latest advances in excitation and detection technology with mature software and a smart design, the analytical performance of the new benchtop instrument approaches the one of more powerful and floor-standing spectrometers.

Product managers Lieven Kempenaers and Michel Zoontjes will demonstrate the new Epsilon 4 during this free webinar. A demonstration shows the ease-of-use, of the instrument, from setting up a measurement, creating dedicated calibrations to analysing routine samples. Discover what impact the new Epsilon 4 could have on your daily operations.

This webinar will take place on 19 September from 10:30 to 11:30 (GMT-5:00)

In 1999, Speaker global product manager of benchtop XRF instruments Dr Lieven Kempenaers started his PhD in Chemistry under the direction of Professor K Janssens at the University of Antwerp (Belgium) with a dedicated focus on the use of X-rays in elemental analysis. In the course of his PhD, Lieven wrote many articles of which one was awarded as “best article of the year 2000”.

In 2003, Lieven completed his PhD in Chemistry and used his XRF knowledge and experience as an XRF application specialist and later on as product manager for PANalytical in the Netherlands. In those five years, he gained more knowledge and experience in many industry segments and the respective applications.

From 2008 until 2012 he was relocated to the Asia Pacific (APAC) regional headquarters in Singapore and took on the assignment as APAC Regional Product Manager XRF.
Once back in the Netherlands, he used his APAC experience as the global product manager for the benchtop XRF instruments.

The second speaker Dr Michel Zoontjes started his PhD in Nanotechnology in 2011 under the direction of Professor W G van der Wiel and Prof G Mul at the University of Twente in the Netherland. His subject was visible light water splitting on a chip. In 2015 he received his doctorate degree, after which he started in 2015 as Product Manager XRF at Malvern Panalytical. He is managing the energy dispersive XRF product line.

Anyone interested in energy dispersive x-ray fluorescence (EDXRF) , lab managers, quality control specialists, geologists, material science and analytical chemistry and university staff can attend this webinar to learn about the benefits of Epsilon XRF benchtops as an elemental analysis technique. You can learn how this latest generation technology brings the performance of floor standing systems to the benchtop.

You will learn the latest development in EDXRF, new applications in reach of benchtops and the ease-of-use of Epsilon benchtops.

Demo at your Desk – Mastersizer 3000

This demonstration will give you an introduction to measuring particle size using the Mastersizer 3000. You will be able to take a look at the Mastersizer 3000 and its accessories and we will share the Mastersizer 3000 software with you so that you can follow the measurement process.

Malvern Panalytical will look at the dispersion of a sample measured in liquid using the Hydro EV accessory. This will introduce you to a range of features in the Mastersizer 3000 software, such as the trending of parameters during the measurement, which is a great aid to method development. The company will also show you the data quality feature which gives you feedback on the quality of your measurements as well as on the stability of your results.

Next, we will make some measurements using the Aero dry dispersion unit, to show how easily you can set up a method to get reproducible data on bulk dry materials. There will also be time to ask any questions that you have about laser diffraction and the Mastersizer 3000.

Join Malvern Panalytical in this webinar to learn about how to measure particle size using laser diffraction and the Mastersizer 3000.

You will also see the Mastersizer 3000 in action and follow the wet and dry measurement processes, find out more about the Mastersizer 3000 and its accessories, andlearn about the software features available in the Mastersizer 3000

Rapid Development of Complex Generics: Achieving In-Vitro Q3 Bioequivalence

In the face of increasing pressure on health care access and costs, regulators such as the US Food and Drug Administration (FDA) are actively seeking ways to enable the rapid development and launch of new generic medicines. Within this, there has been significant focus on complex products, such as orally inhaled and nasal drug products (OINDP) and topical creams, where the delivery method and site of action make bioequivalence assessments difficult using traditional in-vivo approaches.

As a result, many off-patent complex drug products are not subject to generic competition. The US FDA has therefore committed to providing improved scientific and regulatory clarity with respect to complex generic drug approvals, leading to the publication of product-specific guidance documents, which outline the requirements for assessing in vitro bioequivalence by considering physicochemical (Q3) equivalence. This webinar will consider the workflows associated with the evaluation of physicochemical (Q3) bioequivalence with reference to the measurement solutions offered by Malvern Panalytical.

In this webinar, the company will introduce a toolbox of physicochemical analysis techniques that are increasingly being employed to assist with the evaluation of physicochemical (Q3) bioequivalence for complex generic drug products in vitro. Example case studies will be shared, including data on topical cream and nasal spray formulations.

This webinar will take place on 25 September from 10:30 to 11:30 (GMT-5:00)

Speaker Paul Kippax is director of product management of Morphology. Researchers engaged in complex generic product formulation development, scientists engaged in applying in-vitro techniques for bio-equivalence studies and lead scientists considering the technique requirements for assessing bio-equivalence should attend the webinar to learn why physicochemical characterisation studies are important in assessing in-vitro bioequivalence, particularly for complex generic products and which physicochemical properties are considered in assessing Q3 equivalence.

Climate and Hydrology Studies Leveraging ASD VNIR Spectral Snow Albedo Measurements

This webinar will discuss snow and ice applications and the use of Malvern Panalytical’s ASD FieldSpec® spectroradiometer for data measurement and analysis.

It will take place on 27 September from 13:00 to 14:00 (GMT-5:00).

Speaker Dr Mckenzie Skiles is assistant professor at the University of Utah in the Department of Geography. She holds a PhD in Geography from the University of California, and an MS degree in Geography, BS degrees in Geography and Environmental Studies and a GIS certificate from the University of Utah.

McKenzie is a snow optics specialist and has applied her knowledge to investigating the impacts of mineral dust and black carbon deposition on snow. Additional research interests include mountain and snow hydrology, snow energy balance, remote sensing of the cryosphere, and cryosphere-climate interaction.

Those that have interest in snow optics or are involved with snow and ice application studies for climate and environmental monitoring purposes and want to learn how the ASD FieldSpec spectroradiometer can be used for data measurement purposes should attend the webinar.

You will learn the importance of snow optical property studies for earth system models of climate, weather, and hydrology and how the ASD FieldSpec spectroradiometer aids in these studies.