
Mastersizer 3000 – The World’s Most Popular Particle Size Analyzers
The Mastersizer 3000 particle size analyzer is a versatile, compact tool that aligns with the analytical needs, resource constraints and demanding workflows of today’s labs.
Safe, effective medicines can change the world for the better. Malvern Panalytical collaborates with our customers, applying our bespoke blend of analytical expertise and in-house contract development and manufacturing services to help you make these products efficiently and cost-effectively.
Safe, effective medicines can change the world for the better. Malvern Panalytical collaborates with our customers, applying our bespoke blend of analytical expertise and in-house contract development and manufacturing services to help you make these products efficiently and cost-effectively.
When you build on firm foundations you create high-performing products with absolute confidence. Our technologies and experts answer the scientific ‘whys’ and ‘hows’, to ensure even the smallest detail is just right, while reducing risk, saving time, and avoiding costly errors.
Need to accelerate the latest blockbuster drug to market? Worried about selecting the best method to ensure quality control for a critical vaccine? Weighed down by a challenging product formulation problem? We’ll work with you, in the way that best fits your processes and needs, to develop the right way forward.
This is the power of Malvern Panalytical. Insightful, informed, and integrated support for pharmaceutical product development and manufacture. We deal with the details so you can deliver the medicines our world needs.
Malvern Panalytical’s instruments are deployed across the pharmaceutical industry for discovery, development and manufacturing applications. Whether developing new, ground-breaking drugs or generic formulations, both the time and cost associated with pharmaceutical development is significant. In addition, work-flow efficiencies may be achieved when these tools are used in conjunction with each other.
Malvern Panalytical is focused on providing well-designed, innovative analytical instruments, which follow the quality by design (QbD) ethos in the fields of drug discovery, chemical and formulation development, and pharmaceutical manufacturing.
The company understands what is involved in the development and manufacturing of a drug product and the requirements to measure the critical material attributes (CMA), as well as critical quality attributes (CQA) affecting the critical process parameters (CPP) in the manufacturing process.
High throughput screening of large libraries of chemical compounds is the dominant technique used in early stage drug discovery, with dynamic light scattering being the optimum tool.
Being able to measure very small particle size at low concentrations, it is ideally suited as a screening tool for identifying even small levels of aggregation and potential inhibition.
In order to monitor efficacy of the suspension accurately, administering trial drug candidates in this form requires accurate, repeatable and validatable control of the active ingredient’s particle size, often on limited sample volumes.
Laser diffraction is the best tool to meet these pre-formulation requirements. This technique provides particle size distribution of nano-scale material, while also having a wide dynamic range.
When characterising bioavailability or bioequivalence of nasally administered drugs, in support of new drug applications (NDAs) or abbreviated new drug applications (ANDAs), for nasal aerosols and sprays, the US Food and Drug Administration (FDA) recommends several tests.
In cases where the active component or components are suspensions, one important attribute is the drug particle size distribution. A laser diffraction system fit for this purpose must be able to rapidly measure obscuration (optical concentration), in addition to changes in droplet size distribution and span in real-time over the life of a single actuation from the drug delivery device.
The size of a liposomal vesicle plays a pivotal role in the pharmacokinetic and pharmacodynamics attributes of chemotherapeutic drugs, with the liposome acting as a carrier of the drug to the site of action and dynamic light scattering can be an effective technique.
Triple-detection size exclusion chromatography (TD-SEC) can accurately characterise polymer excipient molecular size and weight and avoid incorrect determination. The conditions of a tablet coating process can be simulated using a rotational rheometer system.
The viscosity of the liquid coating is measured initially under low stress conditions to quantify its full structure, then at high shear rates to simulate spraying, and again at low stress conditions to assess the viscosity rebuild with time.
Granulation can improve the ease of handling of powder blends and prevents the segregation of fine constituents, improving consistency in subsequent process steps, principally tableting.
To improve the efficiency of the milling operation, and deliver more consistent milled particle sizes, online particle-size analysis is a solution for continuous milling monitoring and control. In addition, measurements made by the online analyser can control the process through a closed loop with the mill’s programmable logic controller (PLC).
Founded in the late-1960s as Malvern Instruments, Malvern Panalytical is now one of the world’s leading materials and biophysical characterisation companies.
Having built on a long-established reputation for innovation in particle sizing, the company today is highly respected for its technology and applications leadership in areas that range from particle, protein and macromolecule characterisation through to rheological properties measurement and into process optimisation.
Malvern Panalytical understands that when a customer chooses to invest in a Malvern Panalytical product, that customer is making a serious financial commitment. The company takes this seriously, and strives to ensure that the customer is reminded that they will receive exceptional and personalised support for the many years they will have Malvern Panalytical equipment.
Please contact Malvern Panalytical with your business enquiry.
The Mastersizer 3000 particle size analyzer is a versatile, compact tool that aligns with the analytical needs, resource constraints and demanding workflows of today’s labs.
The Zetasizer Advance range offers particle size, particle charge (zeta potential) and molecular weight analysis as well as advances such as adaptive correlation, M3-PALS zeta analysis, constant current zeta mode and a data quality advice software.
The Morphologi 4 is a fully automated static image analysis system that provides a complete detailed description of the morphological properties of particulate materials.
OMNISEC is a Gel Permeation Chromatography (GPC) / Size Exclusion Chromatography (SEC) system for the measurement of absolute molecular weight, molecular size, intrinsic viscosity, branching and other parameters.
Aeris is an easy-to-operate and user-friendly benchtop X-ray diffractometer.
The ultimate X-ray platform for the analysis of powders, thin films, nanomaterials, and solid objects.
The NanoSight range of instruments utilizes nanoparticle tracking analysis (NTA) to characterize nanoparticles from 10nm - 1000nm* in solution.
Measure spray particle and spray droplet size distributions in real-time for efficient product development of sprays and aerosols.
The MicroCal range of microcalorimeters are powerful, analytical tools used to study biological systems, including interactions between molecules as well as changes in conformation such as protein unfolding.
Insitec systems provide continuous online analysis of particle size to ensuring economical, efficient monitoring of industrial processes.
Differential Scanning Calorimetry (DSC) is a technique for understanding the stability of proteins and other biomolecules.
Differential Scanning Calorimetry (DSC) measures the heat change during denaturation of biothermal samples, particularly engineered proteins and biopharmaceutical products.
This presentation provides an overview of gel permeation chromatography (GPC), including what it is and some common applications.
Automated image analysis brings significant advantages over manual light microscopy. Learn here the guidelines that can help improve the value and experience of this technique.
This white paper explores a number of ways that today's modern, laboratory-based powder x-ray diffraction (PXRD) instrumentation and advanced software can greatly assist pharmaceutical scientists in their quest to develop high-quality, stable products and accelerate their speed-to-market.
Nasal spray products are increasingly valued for delivering systemic, as well as locally acting therapies, most notably hormone and migraine treatments.
This white paper provides a general introduction to X-ray Fluorescence (CRF) spectrometry and XRF analysis. It explains how a spectrometer works and how XRF analysis is achieved.
The European Molecular Biology Laboratory (EMBL) is developing a facility within the Barcelona Biomedical Research Park (PRBB) campus in Spain.
Malvern Panalytical, manufacturer of analytical systems, and Concept Life Sciences (CLS), a contract research organisation, have today announced a full business integration. The integration will expand Amplify Analytics, the companies' existing analytical instrument and service relationship, to include CLS's chemistry and biology services. Both entities are operating businesses within the Spectris Group.
13 April 2021Malvern Panalytical is pleased to announce the launch of an innovative version of its Aeris compact X-ray diffractometer (XRD).
25 February 2021Below are the forthcoming shows that will exhibit Malvern’s pharmaceutical solutions in 2020.
1 July 2020Malvern Panalytical acknowledges that positive communication can ‘bring people together’ even when we must isolate.
14 May 2020We recognise that the data our analytical systems give to our clients is critical for informing the development of innovative products or guaranteeing product quality is preserved during manufacture.
7 April 2020Malvern Panalytical (Malvern, UK) and Concept Life Sciences (Cheshire, UK) have launched a new partnership that combines advanced instrumentation with expert analytical services for discovery and development.
31 March 2020NETZSCH has revealed the extension of its product portfolio with the Kinexus rotational rheometers and Rosand capillary rheometers, previously developed and distributed by Malvern Panalytical.
4 February 2020Below are the forthcoming shows that will exhibit Malvern’s pharmaceutical solutions.
26 November 2019Dolomite Microfluidics, based in Royston, UK, is a brand of Blacktrace Holdings Ltd, a company which develops and manufactures groundbreaking technologies for applications in biology, chemistry, microfluidics and nanomaterials.
30 October 2019In 2016, Metals and Additives LLC, a leading manufacturer and supplier of powder additives for the battery and plastics industries, purchased the Mastersizer 3000 from Malvern Panalytical.
23 October 2019On 13-16 October in Boston, Massachusetts, US, ASTM International, a world-leading standards developer, will hold its board meeting and related events.
4 October 2019Typically, when an individual is suffering from minor ailments at home, such as a headache, heartburn or a common cold, medications such as paracetamol, indigestion liquid and cold remedies are used in an attempt to alleviate symptoms. However, the reliability of these products can sometimes be questionable.
8 August 2019The New Model in Technology and Engineering (NMiTE) has announced three appointments to its Board of Trustees.
9 July 2019Malvern Panalytical has announced its next round of webinars. Find out more below. If you are interested in attending any of these events, please send an enquiry to find out how to register.
2 July 2019Malvern Panalytical has announced the next wave of webinars, seminars and conferences for June.
24 May 2019The next generation of Epsilon 1 X-ray fluorescence (XRF) spectrometers has been launched today by Malvern Panalytical.
2 May 2019Malvern Panalytical has announced the next set of webinars for the November and December period, including a particle size masterclass, ‘Using Rheology to Characterise Asphalt for Roofing Applications’ and 'Major Advancement in the Elemental Analysis of Metal Sulfides'. If you are interested in attending any of these events, please make an enquiry using the form on this page.
2 November 2018Malvern Panalytical has announced its latest set of seminars for the November/December period, including a NanoSight workshop, an OMA user day and a DLS Workshop. If you are interested in attending any of the events or have any questions, please make an enquiry using the form on this page.
30 October 2018Malvern has announced a series of seminars taking place throughout September and October. If you are interested in attending any of the events and have any questions, please make an enquiry using the form on this page.
12 September 2018Malvern Panalytical has announced its next batch of webinars this month.
30 August 2018Liposomes are nowadays frequently used as drug delivery systems, and as such requires that they are well characterised for manufacturing and batch release. This characterisation includes their size and size distribution.
7 August 2018For virus development and production, it is important to know the virus concentration at different stages of the process, to optimise the clone used and the production yields.
31 July 2018Malvern Panalytical has announced a number of webinars and seminars occurring throughout August and September.
27 July 2018Malvern Panalytical has announced a wide range of upcoming webinars throughout July, including ‘Enter a New Dimension of X-Ray Diffraction Analysis’ and ‘Applications of Light Scattering and Intrinsic Viscosity Detectors with Size Exclusion Chromatography SEC in Characterising Biopharmaceutical and Other Polymers’. To register for any of these webinars, please either make an enquiry using the form on this page or visit www.malvernpanalytical.com/en/learn/events-and-training/webinars.
9 July 2018This year’s European Powder Diffraction Conference (EPDIC16) is the stage for Malvern Panalytical’s new Empyrean platform, an instrument that redefines the concept of multipurpose X-ray diffraction.
3 July 2018Malvern Panalytical has announced it will be hosting a number of seminars, including ‘One-on-One Breakfast Catch-up on the Latest Powder XRD’, ‘XRF Demonstration (Singapore)’ and ‘Pharma & Food Sector Seminar’.
13 June 2018Malvern Panalytical has announced some key webinars taking place this month, including ‘A Basic Introduction to Rheology and Rheometry – Part Two, Viscoelectricity’ and ‘Enter a New Dimension of X-ray Diffraction Analysis’. To register for either of these events, please make an enquiry using the form on this page, or visit www.malvernpanalytical.com/en/learn/events-and-training.
6 June 2018Malvern Panalytical has introduced its new Zetasizer® Pro and Ultra systems.
23 May 2018Malvern Panalytical has announced a series of webinars taking place in May, including ‘The Live Launch of the New Zetasizer Pro and Zetasizer Ultra’, ‘A Basic Introduction to Rheology and Rheometry PART 1 – Viscosity’, ‘Enlightening the Fcab-antigen Interaction via X-ray Crystallography & Solution Studies’, ‘Get the best of both worlds: Coupling advanced multi-detection with UPLC for faster and more detailed polymer analysis’, and ‘Collecting X-ray Powder Diffraction Data: How to Choose the Best Configuration and Measurement Parameters’.
3 May 2018Malvern Panalytical has announced three webinars in April: ‘X-ray Characterisation of Catalysts’, ‘Get the Best of Both Worlds’, and ‘TerraSpec® Halo Best Practices, Tips & Tricks’.
13 April 2018Malvern Panalytical has announced the Morphologi range, consisting of Morphologi 4 and Morphologi 4-ID.
14 February 2018Expert engineers and scientists at Malvern Panalytical constantly innovate through fundamental research and product development to defy the challenges that face our customers.
7 February 2018Malvern has announced it will be holding a new webinar to explain the use of electrophoretic light scattering (ELS) to measure the electrophoretic mobility of particles or molecules in a solution.
2 February 2018Malvern Panalytical’s new Epsilon 4 can be used to determine the chemical composition of all kinds of material.
31 January 2018Sometimes referred to as photon correlation spectroscopy or quasi-elastic light scattering, dynamic light scattering (DLS) is a technique classically used for measuring the size of particles typically in the sub-micron region, dispersed in a liquid.
25 January 2018Malvern Panalytical has announced a new webinar ‘Characterising Liposome Formation, Structure and Stability with Complementary Techniques’ that will take place this month.
19 January 2018Malvern is hosting a webinar to provide an overview of the nanoparticle characterization platform NanoSight NS300.
12 January 2018Detailed particle characterisation, including shape and size analysis and chemical identification, enables thorough understanding of drug formulations.
11 December 2017Malvern Panalytical has announced the launch of a collaborative project that aims to support the development of existing and next generation biopharmaceutical products.
4 December 2017Malvern will be hosting a wide range of webinars throughout September and October
6 September 2017Supplier of analytical X-ray instrumentation and software PANalytical has announced the introduction of a new Epsilon 1 X-ray fluorescence (XRF) spectrometer.
18 July 2017Understanding the make-up of crystalline structures is a vital aspect of the characterisation of new compounds, and can be regarded as an important first step towards the possibility of tailoring its properties.
11 July 2017A new webinar by Malvern evaluates and discusses size-exclusion chromatography (SEC) data to see the impact of different formulations on monoclonal antibodies and biosimilar molecules.
26 April 2017Malvern presents a webinar discussing the differences between rheometers and viscometers.
6 April 2017Malvern has announced two upcoming webinars this month: Differential scanning calorimetry (robust and powerful physical characterisation of therapeutic protein products) and Cement (composition, structure, and fineness - we are stronger together!).
7 March 2017Packing density and flow behaviour of metal powders has an effect on manufacturing efficiency of powder bed additives.
20 February 2017Malvern has announced it will be unveiling its new protein stability characterisation product for regulated environments MicroCal PEAQ-DSC in an upcoming webinar.
17 February 2017Malvern has announced that it will be presenting a webinar on the basic principles of particle size analysis.
14 February 2017Malvern has announced it will present a webinar discussing the particle tracking analysis (PTA) method (ISO19430) and what it means for nanoparticle measurements.
6 February 2017If you are attending Pittcon this year, why not register for Malvern's short courses, which are taught by recognised characterisation experts.
1 February 2017Malvern has announced it will be hosting a webinar about the use of laser diffraction as a technique in characterising nebulisers and how it is helpful in understanding the delivery of the drug product.
23 January 2017Malvern has announced it will host a webinar to discuss how to measure zeta surface potential.
17 January 2017Size exclusion chromatography (SEC) is a popular analytical technique for studying protein molecular weight, oligomeric state, aggregation, and conjugation.
11 January 2017Malvern has announced it will host a live-panel webinar for the discussion of challenges submitted in an online form on the company's website.
12 December 2016Malvern has announced it will be hosting a webinar discussing gel permeation chromatography (GPC), which is also known as size exclusion chromatography (SEC).
5 December 2016Malvern has announced its latest webinar discussing the types of technologies used for analysing particulates in injectable drugs.
24 November 2016Advancements in portable electronic devices such as mobile phones and laptops has increased demand for advances in battery technology.
9 November 2016Malvern has announced it will host a webinar discussing the use of a diffusion interaction parameter (kD) measurement for the Taylor dispersion analysis in early stages of development.
8 November 2016Malvern will be hosting a webinar to discuss the rheological requirements of paintings and coatings, as well as how they can be measured using a rotational rheometer.
3 November 2016Malvern has announced it will be hosting a webinar to showcase new measurer NanoSight NS3000, which uses Nanoparticle Tracking Analysis (NTA).
10 October 2016Cosmetics, paints, inks, paper, drug delivery, personal care, food or intra-lipid emulsions are made up of multi component chemistries.
8 September 2016The food and drug administration (FDA) has used Malvern's Morphologi G3-ID system to generate key data for the approval of the first generic nasal spray containing mometasone furoate.
18 August 2016Malvern Instruments has launched the new Zetasizer AT, a robust, online, automated analyzer that uses dynamic light scattering (DLS) to automatically measure the size of nanoparticles in suspensions and emulsions.
7 June 2016Malvern is proud to announce they will be hosting a webinar on 8 March at 10:30AM EDT.
7 March 2016Researchers working on the European Metrology Research Project NanoChOp (Chemical and Optical Characterisation of Nanomaterials in Biological Systems), funded by EURAMET, have concluded the NanoSight Nanoparticle Tracking Analysis system offers a unique insight into the behaviour of nanoparticles in biological systems.
4 March 2016Malvern has highlighted its ongoing commitment to extending and supporting the application of NanoSight, a nanoparticle characterisation technology with unique capabilities, by releasing new software and expanding the global technical specialist team.
11 December 2015Malvern Instruments and Bio-Rad from Hercules, California, are collaborating to deliver new analytical tools for the rapid identification of unknown particles.
3 December 2015Particle Characterization Laboratories director William Bernt has highlighted the impact of adding a Malvern NanoSight nanoparticle tracking analysis (NTA) system to the toolkit for nanoparticles.
2 November 2015New tools from Malvern that address specific analytical challenges in biopharma development will take centre stage at this year's AAPS Annual Meeting and Exposition, in Orlando, US.
14 October 2015Insight from CP Kelco, a global leader in the specialty hydrocolloids market, provides a blueprint for the intelligent, cost-efficient deployment of gel permeation/size exclusion chromatography (GPC/SEC) in biopolymer manufacture.
24 September 2015Malvern has opened a new biopharmaceutical applications laboratory in San Diego.
19 September 2015Malvern Instruments has launched an improved rSolution platform on their Kinexus rotational rheometer.
18 September 2015Researchers in the department of Chemical and Biomolecular Engineering at Ohio State University, Columbus, Ohio, US, are using Malvern's NanoSight nanoparticle tracking analysis (NTA) to study extracellular vesicle yields from different cell culture lines.
29 May 2015Malvern has launched a new gel permeation / size exclusion chromatography (GPC / SEC) platform, which delivers high performance and productivity for analytical laboratories.
28 January 2015Malvern Instruments will showcase a new chromatography system and detectors at Pittcon 2015 on 8-12 March in New Orleans, US.
22 January 2015A new whitepaper from Malvern Instruments on oral solid dose (OSD) deformulation demonstrates how the analytical technique of morphologically directed Raman spectroscopy (MDRS) can be used to accelerate development of generic products to a successful conclusion.
14 January 2015Malvern Instruments product development manager for Process Systems Alon Vaisman will speak about two different analytical techniques and their applications, as part of the particle characterisation session at the 2015 International Forum on Process Analytical Technology and Quality by Design (IFPAC) annual meeting.
7 January 2015Malvern Instruments has published a new application note examining the use of NanoSight Nanoparticle Tracking Analysis (NTA) technology in the study of extracellular vesicles.
26 November 2014'Extending the boundaries of QbD', a new whitepaper explores the application of Quality by Design (QbD) principles to the development of analytical instrumentation and its benefits.
21 November 2014Malvern Instruments has released new guidance on using automated image analysis to detect and quantify agglomerates.
14 November 2014Malvern Instruments is attending the American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition at San Diego Convention Center in San Diego.
24 October 2014Malvern Instruments has released new 'third anniversary' accessories for the Mastersizer 3000, helping to reduce the time and cost of developing and validating robust methods for pharmaceutical particle size analysis.
17 October 2014The cross-disciplinary capabilities of Malvern Instruments' technology are being fully exploited at Queen Mary University in London, UK.
11 September 2014Malvern Instruments applications manager Dr Alan Rawle will give a plenary lecture at the Particulate Systems Analysis (PSA) 2014 conference and exhibition, organised by the Royal Society of Chemistry's Particle Characterisation Group.
21 August 2014Researchers at The School of Freshwater Science, University of Wisconsin-Milwaukee, US, are using NanoSight Nanoparticle Tracking Analysis (NTA) from Malvern Instruments to investigate the effects of nanoparticle contaminants on freshwater organisms.
28 July 2014The new Zetasizer Helix from Malvern Instruments enables the detailed study of mechanisms of protein aggregation and is a powerful tool for early stage biopharmaceutical development.
8 July 2014Malvern Instruments Ltd. (Malvern, UK) has announced that it has entered into an agreement with GE Healthcare Life Sciences to acquire the company's MicroCal microcalorimetry business.
8 June 2014Researchers within the the Departement Environnement et Agro-biotechnologies (EVA) of the Centre de Recherche Public - Gabriel Lippmann, Luxembourg, are using the nanoparticle tracking analysis (NTA) technique for the characterisation of nanoparticles within their toxicological studies.
29 May 2014The new Zetasizer NanoSampler from Malvern Instruments is a versatile, compact, fully automated sample delivery system for the Zetasizer Nano, the most widely used system for nanoparticle and colloid characterisation.
9 May 2014Malvern Instruments reports on the publication of the 1,000th peer-reviewed paper to cite the company's NanoSight Nanoparticle Tracking Analysis, NTA. Entitled 'Fumed Silica Nanoparticle Mediated Biomimicry for Optimal Cell-Material Interactions for Artificial Organ Development', it was authored by the research team of professor Alexander Seifalian from University College London.
15 April 2014Dr Alan Rawle, applications manager for Malvern Instruments, has been invited to speak as part of the Brian Scarlett Memorial Session at the 7th World Congress for Particle Technology (WCPT 7), which takes place in Beijing, China, from 19-22 May.
15 April 2014Malvern Instruments has acquired Wiltshire-based NanoSight Ltd, specialists in technology and instruments that are used worldwide to measure the size and other characteristics of nano-sized materials.
29 September 2013Thank you for submitting the form. Your enquiry will be submitted to the company.