Malvern Panalytical Drug Development Technologies

Characterisation technologies

Malvern Panalytical has a wide range of characterisation technologies that can be used to accelerate the drug development process. Its methods are used by scientists and engineers to maximise productivity and increase time-to-market.

Through a range of high-quality, customer-focused characterisation services, Malvern Panalytical delivers cost-effective chemical, physical and structural analysis of materials for the indication of performance in drug products.

Solutions range from tools that can run reliably and unattended, to systems that provide information on several key attributes in a single analysis such as particle size, shape, chemical identity, molecular weight, size, and concentration.

Analysis of materials for development and manufacturing of drugs

Malvern Panalytical’s instruments are deployed across the pharmaceutical industry for discovery, development and manufacturing applications. Whether developing new, ground-breaking drugs or generic formulations, both the time and cost associated with pharmaceutical development is significant. In addition, work-flow efficiencies may be achieved when these tools are used in conjunction with each other.

Malvern Panalytical is focused on providing well-designed, innovative analytical instruments, which follow the quality by design (QbD) ethos in the fields of drug discovery, chemical and formulation development, and pharmaceutical manufacturing.

The company understands what is involved in the development and manufacturing of a drug product and the requirements to measure the critical material attributes (CMA), as well as critical quality attributes (CQA) affecting the critical process parameters (CPP) in the manufacturing process.

Molecule discovery tools

High throughput screening of large libraries of chemical compounds is the dominant technique used in early stage drug discovery, with dynamic light scattering being the optimum tool.

Being able to measure very small particle size at low concentrations, it is ideally suited as a screening tool for identifying even small levels of aggregation and potential inhibition.

Molecule optimisation with laser diffraction

In order to monitor efficacy of the suspension accurately, administering trial drug candidates in this form requires accurate, repeatable and validatable control of the active ingredient’s particle size, often on limited sample volumes.

Laser diffraction is the best tool to meet these pre-formulation requirements. This technique provides particle size distribution of nano-scale material, while also having a wide dynamic range.

Chemical development for drug delivery

When characterising bioavailability or bioequivalence of nasally administered drugs, in support of new drug applications (NDAs) or abbreviated new drug applications (ANDAs), for nasal aerosols and sprays, the US Food and Drug Administration (FDA) recommends several tests.

In cases where the active component or components are suspensions, one important attribute is the drug particle size distribution. A laser diffraction system fit for this purpose must be able to rapidly measure obscuration (optical concentration), in addition to changes in droplet size distribution and span in real-time over the life of a single actuation from the drug delivery device.

Formulation development of drugs

The size of a liposomal vesicle plays a pivotal role in the pharmacokinetic and pharmacodynamics attributes of chemotherapeutic drugs, with the liposome acting as a carrier of the drug to the site of action and dynamic light scattering can be an effective technique.

Triple-detection size exclusion chromatography (TD-SEC) can accurately characterise polymer excipient molecular size and weight and avoid incorrect determination. The conditions of a tablet coating process can be simulated using a rotational rheometer system.

The viscosity of the liquid coating is measured initially under low stress conditions to quantify its full structure, then at high shear rates to simulate spraying, and again at low stress conditions to assess the viscosity rebuild with time.

Online particle analysis for drug manufacturing

Granulation can improve the ease of handling of powder blends and prevents the segregation of fine constituents, improving consistency in subsequent process steps, principally tableting.

To improve the efficiency of the milling operation, and deliver more consistent milled particle sizes, online particle-size analysis is a solution for continuous milling monitoring and control. In addition, measurements made by the online analyser can control the process through a closed loop with the mill’s programmable logic controller (PLC).

Founded in the late-1960s as Malvern Instruments, Malvern Panalytical is now one of the world’s leading materials and biophysical characterisation companies.

Having built on a long-established reputation for innovation in particle sizing, the company today is highly respected for its technology and applications leadership in areas that range from particle, protein and macromolecule characterisation through to rheological properties measurement and into process optimisation.

Malvern Panalytical understands that when a customer chooses to invest in a Malvern Panalytical product, that customer is making a serious financial commitment. The company takes this seriously, and strives to ensure that the customer is reminded that they will receive exceptional and personalised support for the many years they will have Malvern Panalytical equipment.

Please contact Malvern Panalytical with your business enquiry.

Make an enquiry

Press Release

2020 Forthcoming Events

Below are the forthcoming shows that will exhibit Malvern’s pharmaceutical solutions in 2020.

White Papers

Getting Acquainted with the XRF Theory

This white paper provides a general introduction to X-ray Fluorescence (CRF) spectrometry and XRF analysis. It explains how a spectrometer works and how XRF analysis is achieved. 

Malvern Panalytical Images

Press Release

1 July 2020

Below are the forthcoming shows that will exhibit Malvern’s pharmaceutical solutions in 2020.

Read more
14 May 2020

Malvern Panalytical acknowledges that positive communication can ‘bring people together’ even when we must isolate.

Read more
7 April 2020

We recognise that the data our analytical systems give to our clients is critical for informing the development of innovative products or guaranteeing product quality is preserved during manufacture.

Read more
31 March 2020

Malvern Panalytical (Malvern, UK) and Concept Life Sciences (Cheshire, UK) have launched a new partnership that combines advanced instrumentation with expert analytical services for discovery and development.

Read more
4 February 2020

NETZSCH has revealed the extension of its product portfolio with the Kinexus rotational rheometers and Rosand capillary rheometers, previously developed and distributed by Malvern Panalytical.

Read more
26 November 2019

Below are the forthcoming shows that will exhibit Malvern’s pharmaceutical solutions.

Read more
30 October 2019

Dolomite Microfluidics, based in Royston, UK, is a brand of Blacktrace Holdings Ltd, a company which develops and manufactures groundbreaking technologies for applications in biology, chemistry, microfluidics and nanomaterials.

Read more
23 October 2019

In 2016, Metals and Additives LLC, a leading manufacturer and supplier of powder additives for the battery and plastics industries, purchased the Mastersizer 3000 from Malvern Panalytical.

Read more
4 October 2019

On 13-16 October in Boston, Massachusetts, US, ASTM International, a world-leading standards developer, will hold its board meeting and related events.

Read more
8 August 2019

Typically, when an individual is suffering from minor ailments at home, such as a headache, heartburn or a common cold, medications such as paracetamol, indigestion liquid and cold remedies are used in an attempt to alleviate symptoms. However, the reliability of these products can sometimes be questionable.

Read more
9 July 2019

The New Model in Technology and Engineering (NMiTE) has announced three appointments to its Board of Trustees.

Read more
2 July 2019

Malvern Panalytical has announced its next round of webinars. Find out more below. If you are interested in attending any of these events, please send an enquiry to find out how to register. 

Read more
24 May 2019

Malvern Panalytical has announced the next wave of webinars, seminars and conferences for June.

Read more
2 May 2019

The next generation of Epsilon 1 X-ray fluorescence (XRF) spectrometers has been launched today by Malvern Panalytical.

Read more
2 November 2018

Malvern Panalytical has announced the next set of webinars for the November and December period, including a particle size masterclass, ‘Using Rheology to Characterise Asphalt for Roofing Applications’ and 'Major Advancement in the Elemental Analysis of Metal Sulfides'.

If you are interested in attending any of these events, please make an enquiry using the form on this page. 

Read more
30 October 2018

Malvern Panalytical has announced its latest set of seminars for the November/December period, including a NanoSight workshop, an OMA user day and a DLS Workshop. If you are interested in attending any of the events or have any questions, please make an enquiry using the form on this page.

Read more
12 September 2018

Malvern has announced a series of seminars taking place throughout September and October. If you are interested in attending any of the events and have any questions, please make an enquiry using the form on this page.

Read more
30 August 2018

Malvern Panalytical has announced its next batch of webinars this month.

Read more
7 August 2018

Liposomes are nowadays frequently used as drug delivery systems, and as such requires that they are well characterised for manufacturing and batch release. This characterisation includes their size and size distribution.

Read more
31 July 2018

For virus development and production, it is important to know the virus concentration at different stages of the process, to optimise the clone used and the production yields.

Read more
27 July 2018

Malvern Panalytical has announced a number of webinars and seminars occurring throughout August and September.

Read more
9 July 2018

Malvern Panalytical has announced a wide range of upcoming webinars throughout July, including ‘Enter a New Dimension of X-Ray Diffraction Analysis’ and ‘Applications of Light Scattering and Intrinsic Viscosity Detectors with Size Exclusion Chromatography SEC in Characterising Biopharmaceutical and Other Polymers’. To register for any of these webinars, please either make an enquiry using the form on this page or visit

Read more
3 July 2018

This year’s European Powder Diffraction Conference (EPDIC16) is the stage for Malvern Panalytical’s new Empyrean platform, an instrument that redefines the concept of multipurpose X-ray diffraction.

Read more
13 June 2018

Malvern Panalytical has announced it will be hosting a number of seminars, including ‘One-on-One Breakfast Catch-up on the Latest Powder XRD’, ‘XRF Demonstration (Singapore)’ and ‘Pharma & Food Sector Seminar’.

Read more
6 June 2018

Malvern Panalytical has announced some key webinars taking place this month, including ‘A Basic Introduction to Rheology and Rheometry – Part Two, Viscoelectricity’ and ‘Enter a New Dimension of X-ray Diffraction Analysis’. To register for either of these events, please make an enquiry using the form on this page, or visit

Read more
23 May 2018

Malvern Panalytical has introduced its new Zetasizer® Pro and Ultra systems.

Read more
3 May 2018

Malvern Panalytical has announced a series of webinars taking place in May, including ‘The Live Launch of the New Zetasizer Pro and Zetasizer Ultra’, ‘A Basic Introduction to Rheology and Rheometry PART 1 – Viscosity’, ‘Enlightening the Fcab-antigen Interaction via X-ray Crystallography & Solution Studies’, ‘Get the best of both worlds: Coupling advanced multi-detection with UPLC for faster and more detailed polymer analysis’, and ‘Collecting X-ray Powder Diffraction Data: How to Choose the Best Configuration and Measurement Parameters’.

Read more
13 April 2018

Malvern Panalytical has announced three webinars in April: ‘X-ray Characterisation of Catalysts’, ‘Get the Best of Both Worlds’, and ‘TerraSpec® Halo Best Practices, Tips & Tricks’.

Read more
14 February 2018

Malvern Panalytical has announced the Morphologi range, consisting of Morphologi 4 and Morphologi 4-ID.

Read more
7 February 2018

Expert engineers and scientists at Malvern Panalytical constantly innovate through fundamental research and product development to defy the challenges that face our customers.

Read more
2 February 2018

Malvern has announced it will be holding a new webinar to explain the use of electrophoretic light scattering (ELS) to measure the electrophoretic mobility of particles or molecules in a solution.

Read more
31 January 2018

Malvern Panalytical’s new Epsilon 4 can be used to determine the chemical composition of all kinds of material.

Read more
25 January 2018

Sometimes referred to as photon correlation spectroscopy or quasi-elastic light scattering, dynamic light scattering (DLS) is a technique classically used for measuring the size of particles typically in the sub-micron region, dispersed in a liquid.

Read more
19 January 2018

Malvern Panalytical has announced a new webinar ‘Characterising Liposome Formation, Structure and Stability with Complementary Techniques’ that will take place this month.

Read more
12 January 2018

Malvern is hosting a webinar to provide an overview of the nanoparticle characterization platform NanoSight NS300.

Read more
11 December 2017

Detailed particle characterisation, including shape and size analysis and chemical identification, enables thorough understanding of drug formulations.

Read more
4 December 2017

Malvern Panalytical has announced the launch of a collaborative project that aims to support the development of existing and next generation biopharmaceutical products.

Read more
6 September 2017

Malvern will be hosting a wide range of webinars throughout September and October

Read more
18 July 2017

Supplier of analytical X-ray instrumentation and software PANalytical has announced the introduction of a new Epsilon 1 X-ray fluorescence (XRF) spectrometer.

Read more
11 July 2017

Understanding the make-up of crystalline structures is a vital aspect of the characterisation of new compounds, and can be regarded as an important first step towards the possibility of tailoring its properties.

Read more
26 April 2017

A new webinar by Malvern evaluates and discusses size-exclusion chromatography (SEC) data to see the impact of different formulations on monoclonal antibodies and biosimilar molecules.

Read more
6 April 2017

Malvern presents a webinar discussing the differences between rheometers and viscometers.

Read more
7 March 2017

Malvern has announced two upcoming webinars this month: Differential scanning calorimetry (robust and powerful physical characterisation of therapeutic protein products) and Cement (composition, structure, and fineness - we are stronger together!).

Read more
20 February 2017

Packing density and flow behaviour of metal powders has an effect on manufacturing efficiency of powder bed additives.

Read more
17 February 2017

Malvern has announced it will be unveiling its new protein stability characterisation product for regulated environments MicroCal PEAQ-DSC in an upcoming webinar.

Read more
14 February 2017

Malvern has announced that it will be presenting a webinar on the basic principles of particle size analysis.

Read more
6 February 2017

Malvern has announced it will present a webinar discussing the particle tracking analysis (PTA) method (ISO19430) and what it means for nanoparticle measurements.

Read more
1 February 2017

If you are attending Pittcon this year, why not register for Malvern's short courses, which are taught by recognised characterisation experts.

Read more
23 January 2017

Malvern has announced it will be hosting a webinar about the use of laser diffraction as a technique in characterising nebulisers and how it is helpful in understanding the delivery of the drug product.

Read more
17 January 2017

Malvern has announced it will host a webinar to discuss how to measure zeta surface potential.

Read more
11 January 2017

Size exclusion chromatography (SEC) is a popular analytical technique for studying protein molecular weight, oligomeric state, aggregation, and conjugation.

Read more
12 December 2016

Malvern has announced it will host a live-panel webinar for the discussion of challenges submitted in an online form on the company's website.

Read more
5 December 2016

Malvern has announced it will be hosting a webinar discussing gel permeation chromatography (GPC), which is also known as size exclusion chromatography (SEC).

Read more
24 November 2016

Malvern has announced its latest webinar discussing the types of technologies used for analysing particulates in injectable drugs.

Read more
9 November 2016

Advancements in portable electronic devices such as mobile phones and laptops has increased demand for advances in battery technology.

Read more
8 November 2016

Malvern has announced it will host a webinar discussing the use of a diffusion interaction parameter (kD) measurement for the Taylor dispersion analysis in early stages of development.

Read more
3 November 2016

Malvern will be hosting a webinar to discuss the rheological requirements of paintings and coatings, as well as how they can be measured using a rotational rheometer.

Read more
10 October 2016

Malvern has announced it will be hosting a webinar to showcase new measurer NanoSight NS3000, which uses Nanoparticle Tracking Analysis (NTA).

Read more
8 September 2016

Cosmetics, paints, inks, paper, drug delivery, personal care, food or intra-lipid emulsions are made up of multi component chemistries.

Read more
18 August 2016

The food and drug administration (FDA) has used Malvern's Morphologi G3-ID system to generate key data for the approval of the first generic nasal spray containing mometasone furoate.

Read more
7 June 2016

Malvern Instruments has launched the new Zetasizer AT, a robust, online, automated analyzer that uses dynamic light scattering (DLS) to automatically measure the size of nanoparticles in suspensions and emulsions.

Read more
7 March 2016

Malvern is proud to announce they will be hosting a webinar on 8 March at 10:30AM EDT.

Read more
4 March 2016

Researchers working on the European Metrology Research Project NanoChOp (Chemical and Optical Characterisation of Nanomaterials in Biological Systems), funded by EURAMET, have concluded the NanoSight Nanoparticle Tracking Analysis system offers a unique insight into the behaviour of nanoparticles in biological systems.

Read more
11 December 2015

Malvern has highlighted its ongoing commitment to extending and supporting the application of NanoSight, a nanoparticle characterisation technology with unique capabilities, by releasing new software and expanding the global technical specialist team.

Read more
3 December 2015

Malvern Instruments and Bio-Rad from Hercules, California, are collaborating to deliver new analytical tools for the rapid identification of unknown particles.

Read more
2 November 2015

Particle Characterization Laboratories director William Bernt has highlighted the impact of adding a Malvern NanoSight nanoparticle tracking analysis (NTA) system to the toolkit for nanoparticles.

Read more
14 October 2015

New tools from Malvern that address specific analytical challenges in biopharma development will take centre stage at this year's AAPS Annual Meeting and Exposition, in Orlando, US.

Read more
24 September 2015

Insight from CP Kelco, a global leader in the specialty hydrocolloids market, provides a blueprint for the intelligent, cost-efficient deployment of gel permeation/size exclusion chromatography (GPC/SEC) in biopolymer manufacture.

Read more
19 September 2015

Malvern has opened a new biopharmaceutical applications laboratory in San Diego.

Read more
18 September 2015

Malvern Instruments has launched an improved rSolution platform on their Kinexus rotational rheometer.

Read more
29 May 2015

Researchers in the department of Chemical and Biomolecular Engineering at Ohio State University, Columbus, Ohio, US, are using Malvern's NanoSight nanoparticle tracking analysis (NTA) to study extracellular vesicle yields from different cell culture lines.

Read more
28 January 2015

Malvern has launched a new gel permeation / size exclusion chromatography (GPC / SEC) platform, which delivers high performance and productivity for analytical laboratories.

Read more
22 January 2015

Malvern Instruments will showcase a new chromatography system and detectors at Pittcon 2015 on 8-12 March in New Orleans, US.

Read more
14 January 2015

A new whitepaper from Malvern Instruments on oral solid dose (OSD) deformulation demonstrates how the analytical technique of morphologically directed Raman spectroscopy (MDRS) can be used to accelerate development of generic products to a successful conclusion.

Read more
7 January 2015

Malvern Instruments product development manager for Process Systems Alon Vaisman will speak about two different analytical techniques and their applications, as part of the particle characterisation session at the 2015 International Forum on Process Analytical Technology and Quality by Design (IFPAC) annual meeting.

Read more
26 November 2014

Malvern Instruments has published a new application note examining the use of NanoSight Nanoparticle Tracking Analysis (NTA) technology in the study of extracellular vesicles.

Read more
21 November 2014

'Extending the boundaries of QbD', a new whitepaper explores the application of Quality by Design (QbD) principles to the development of analytical instrumentation and its benefits.

Read more
14 November 2014

Malvern Instruments has released new guidance on using automated image analysis to detect and quantify agglomerates.

Read more
24 October 2014

Malvern Instruments is attending the American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition at San Diego Convention Center in San Diego.

Read more
17 October 2014

Malvern Instruments has released new 'third anniversary' accessories for the Mastersizer 3000, helping to reduce the time and cost of developing and validating robust methods for pharmaceutical particle size analysis.

Read more
11 September 2014

The cross-disciplinary capabilities of Malvern Instruments' technology are being fully exploited at Queen Mary University in London, UK.

Read more
21 August 2014

Malvern Instruments applications manager Dr Alan Rawle will give a plenary lecture at the Particulate Systems Analysis (PSA) 2014 conference and exhibition, organised by the Royal Society of Chemistry's Particle Characterisation Group.

Read more
28 July 2014

Researchers at The School of Freshwater Science, University of Wisconsin-Milwaukee, US, are using NanoSight Nanoparticle Tracking Analysis (NTA) from Malvern Instruments to investigate the effects of nanoparticle contaminants on freshwater organisms.

Read more
8 July 2014

The new Zetasizer Helix from Malvern Instruments enables the detailed study of mechanisms of protein aggregation and is a powerful tool for early stage biopharmaceutical development.

Read more
8 June 2014

Malvern Instruments Ltd. (Malvern, UK) has announced that it has entered into an agreement with GE Healthcare Life Sciences to acquire the company's MicroCal microcalorimetry business.

Read more
29 May 2014

Researchers within the the Departement Environnement et Agro-biotechnologies (EVA) of the Centre de Recherche Public - Gabriel Lippmann, Luxembourg, are using the nanoparticle tracking analysis (NTA) technique for the characterisation of nanoparticles within their toxicological studies.

Read more
9 May 2014

The new Zetasizer NanoSampler from Malvern Instruments is a versatile, compact, fully automated sample delivery system for the Zetasizer Nano, the most widely used system for nanoparticle and colloid characterisation.

Read more
15 April 2014

Malvern Instruments reports on the publication of the 1,000th peer-reviewed paper to cite the company's NanoSight Nanoparticle Tracking Analysis, NTA. Entitled 'Fumed Silica Nanoparticle Mediated Biomimicry for Optimal Cell-Material Interactions for Artificial Organ Development', it was authored by the research team of professor Alexander Seifalian from University College London.

Read more
15 April 2014

Dr Alan Rawle, applications manager for Malvern Instruments, has been invited to speak as part of the Brian Scarlett Memorial Session at the 7th World Congress for Particle Technology (WCPT 7), which takes place in Beijing, China, from 19-22 May.

Read more
29 September 2013

Malvern Instruments has acquired Wiltshire-based NanoSight Ltd, specialists in technology and instruments that are used worldwide to measure the size and other characteristics of nano-sized materials.

Read more

Regional Offices


Malvern Canada

4995 Levy Street


H4R 2N9



+1 800 932 0101 +1 508 768 6403

Malvern Instruments China

Unit 101, XinAn Plaza

Building 13

No 99 Tianzhou Road




+86 21 6113 3777 +86 4006 306 902 +86 8008 206 902 +86 4008 206 902 +86 21 6113 3778

Malvern Instruments Nordic AB

Korskildelund 6

DK-2670 Greve



+45 369 151 00 +45 369 151 01

Malvern Instruments Nordic OY

Kumitehtaankatu 5


FIN-04260 Kerava



+ 358 968 995 231 +358 968 995 232

Malvern Instruments SA

Parc Club de l'Université

30 Rue Jean Rostand

91893 Orsay Cedex



+33 169 351 800 +33 160 191 326
Malvern Instruments GmbH

Marie-Curie-Str. 4/1

71083 Herrenberg


+49 703 297 770 +49 703 277 854

Malvern Aimil Instruments Pvt Ltd BSEL Tech Park

11th floor Sector - 30A

Opp Vashi Railway Station


Navi Mumbai 400 705



+91 22 3964 6600 +91 22 3964 6666

North Bldg 511 Kobe International Business Center

5-5-2 Minatojimaminami-machi Chuo-ku


Hyogo Prefecture 650-0047



+81 78 306 3806 0120 57 17 14 +81 78 306 3807

Malvern Instruments Korea 7F SH Energy B/D

16-6 Sunae-Dong

Bundang-Gu, Seongnam-City



South Korea

+82 31 786 0840 +82 31 786 0950

Malvern Instruments

Av. De La Industria No 300

San Pedro Garza Garcia

C.P. 66279

Nuevo Leon


+52 5556 846 548

Malvern Instruments Nordic AB

Lokkeasveien 22A

N-3138 Skallestad



+47 333 87 328 +47 333 87 329

Malvern Instruments Nordic AB

Vallongatan 1

752 28 Uppsala

Uppsala County


+46 185 52 455 +46 185 51 114
United States of America

Malvern Instruments Inc

117 Flanders Road


MA 01581-1042


United States of America

+1 508 768 6400 +1 508 768 6403

Go Top