Malvern Panalytical

Drug Development Technologies

Enigma Business Park, Grovewood Road, Malvern, WR14 1XZ,Worcestershire, United Kingdom



Characterisation technologies

Malvern Panalytical has a wide range of characterisation technologies that can be used to accelerate the drug development process. Its methods are used by scientists and engineers to maximise productivity and increase time-to-market.

Through a range of high-quality, customer-focused characterisation services, Malvern Panalytical delivers cost-effective chemical, physical and structural analysis of materials for the indication of performance in drug products.

Solutions range from tools that can run reliably and unattended, to systems that provide information on several key attributes in a single analysis such as particle size, shape, chemical identity, molecular weight, size, and concentration.

Analysis of materials for development and manufacturing of drugs

Malvern Panalytical’s instruments are deployed across the pharmaceutical industry for discovery, development and manufacturing applications. Whether developing new, ground-breaking drugs or generic formulations, both the time and cost associated with pharmaceutical development is significant. In addition, work-flow efficiencies may be achieved when these tools are used in conjunction with each other.

Malvern Panalytical is focused on providing well-designed, innovative analytical instruments, which follow the quality by design (QbD) ethos in the fields of drug discovery, chemical and formulation development, and pharmaceutical manufacturing.

The company understands what is involved in the development and manufacturing of a drug product and the requirements to measure the critical material attributes (CMA), as well as critical quality attributes (CQA) affecting the critical process parameters (CPP) in the manufacturing process.

Molecule discovery tools

High throughput screening of large libraries of chemical compounds is the dominant technique used in early stage drug discovery, with dynamic light scattering being the optimum tool.

Being able to measure very small particle size at low concentrations, it is ideally suited as a screening tool for identifying even small levels of aggregation and potential inhibition.

Molecule optimisation with laser diffraction

In order to monitor efficacy of the suspension accurately, administering trial drug candidates in this form requires accurate, repeatable and validatable control of the active ingredient’s particle size, often on limited sample volumes.

Laser diffraction is the best tool to meet these pre-formulation requirements. This technique provides particle size distribution of nano-scale material, while also having a wide dynamic range.

Chemical development for drug delivery

When characterising bioavailability or bioequivalence of nasally administered drugs, in support of new drug applications (NDAs) or abbreviated new drug applications (ANDAs), for nasal aerosols and sprays, the US Food and Drug Administration (FDA) recommends several tests.

In cases where the active component or components are suspensions, one important attribute is the drug particle size distribution. A laser diffraction system fit for this purpose must be able to rapidly measure obscuration (optical concentration), in addition to changes in droplet size distribution and span in real-time over the life of a single actuation from the drug delivery device.

Formulation development of drugs

The size of a liposomal vesicle plays a pivotal role in the pharmacokinetic and pharmacodynamics attributes of chemotherapeutic drugs, with the liposome acting as a carrier of the drug to the site of action and dynamic light scattering can be an effective technique.

Triple-detection size exclusion chromatography (TD-SEC) can accurately characterise polymer excipient molecular size and weight and avoid incorrect determination. The conditions of a tablet coating process can be simulated using a rotational rheometer system.

The viscosity of the liquid coating is measured initially under low stress conditions to quantify its full structure, then at high shear rates to simulate spraying, and again at low stress conditions to assess the viscosity rebuild with time.

Online particle analysis for drug manufacturing

Granulation can improve the ease of handling of powder blends and prevents the segregation of fine constituents, improving consistency in subsequent process steps, principally tableting.

To improve the efficiency of the milling operation, and deliver more consistent milled particle sizes, online particle-size analysis is a solution for continuous milling monitoring and control. In addition, measurements made by the online analyser can control the process through a closed loop with the mill’s programmable logic controller (PLC).

Founded in the late-1960s as Malvern Instruments, Malvern Panalytical is now one of the world’s leading materials and biophysical characterisation companies.

Having built on a long-established reputation for innovation in particle sizing, the company today is highly respected for its technology and applications leadership in areas that range from particle, protein and macromolecule characterisation through to rheological properties measurement and into process optimisation.

Malvern Panalytical understands that when a customer chooses to invest in a Malvern Panalytical product, that customer is making a serious financial commitment. The company takes this seriously, and strives to ensure that the customer is reminded that they will receive exceptional and personalised support for the many years they will have Malvern Panalytical equipment.

Please contact Malvern Panalytical with your business enquiry.

Viscotek Range of GPC / SEC Systems

The Viscotek range comprises of complete systems, software and detectors, which are all supported by Malvern's worldwide network to provide training and advice.

Zetasizer AT for Dynamic Light Scattering

Malvern Panalytical's Zetasizer AT brings the dynamic light scattering (DLS) technology of the Zetasizer Nano to the process development and manufacturing arena, enabling real-time monitoring of nanoscale particle processes online.

Pharmaceutical Challenges Aided by Laboratory Powder X-ray Diffraction

This white paper explores a number of ways that today's modern, laboratory-based powder x-ray diffraction (PXRD) instrumentation and advanced software can greatly assist pharmaceutical scientists in their quest to develop high-quality, stable products and accelerate their speed-to-market.

Getting Acquainted with the XRF Theory

This white paper provides a general introduction to X-ray Fluorescence (CRF) spectrometry and XRF analysis. It explains how a spectrometer works and how XRF analysis is achieved. 

2020 Forthcoming Events

Below are the forthcoming shows that will exhibit Malvern’s pharmaceutical solutions in 2020.

Contract Research Services

We recognise that the data our analytical systems give to our clients is critical for informing the development of innovative products or guaranteeing product quality is preserved during manufacture.

Unlocking the Power of Expert Analytics

Malvern Panalytical (Malvern, UK) and Concept Life Sciences (Cheshire, UK) have launched a new partnership that combines advanced instrumentation with expert analytical services for discovery and development.

Pharmaceutical Drug Development and Particle Sizing

Typically, when an individual is suffering from minor ailments at home, such as a headache, heartburn or a common cold, medications such as paracetamol, indigestion liquid and cold remedies are used in an attempt to alleviate symptoms. However, the reliability of these products can sometimes be questionable.

Malvern Panalytical to Host Webinars this Month

Malvern Panalytical has announced its next round of webinars. Find out more below. If you are interested in attending any of these events, please send an enquiry to find out how to register. 

Malvern Panalytical Announces New Webinars for November

Malvern Panalytical has announced the next set of webinars for the November and December period, including a particle size masterclass, ‘Using Rheology to Characterise Asphalt for Roofing Applications’ and 'Major Advancement in the Elemental Analysis of Metal Sulfides'. If you are interested in attending any of these events, please make an enquiry using the form on this page. 

Malvern Panalytical’s Latest Seminars

Malvern Panalytical has announced its latest set of seminars for the November/December period, including a NanoSight workshop, an OMA user day and a DLS Workshop. If you are interested in attending any of the events or have any questions, please make an enquiry using the form on this page.

Malvern Panalytical Announces Next Batch of Seminars

Malvern has announced a series of seminars taking place throughout September and October. If you are interested in attending any of the events and have any questions, please make an enquiry using the form on this page.

Characterising the Size and Concentration of Liposomes

Liposomes are nowadays frequently used as drug delivery systems, and as such requires that they are well characterised for manufacturing and batch release. This characterisation includes their size and size distribution.

Malvern Panalytical’s July Webinars

Malvern Panalytical has announced a wide range of upcoming webinars throughout July, including ‘Enter a New Dimension of X-Ray Diffraction Analysis’ and ‘Applications of Light Scattering and Intrinsic Viscosity Detectors with Size Exclusion Chromatography SEC in Characterising Biopharmaceutical and Other Polymers’. To register for any of these webinars, please either make an enquiry using the form on this page or visit www.malvernpanalytical.com/en/learn/events-and-training/webinars.

Upcoming Malvern Panalytical Seminars

Malvern Panalytical has announced it will be hosting a number of seminars, including ‘One-on-One Breakfast Catch-up on the Latest Powder XRD’, ‘XRF Demonstration (Singapore)’ and ‘Pharma & Food Sector Seminar’.

Malvern Panalytical’s June Webinars

Malvern Panalytical has announced some key webinars taking place this month, including ‘A Basic Introduction to Rheology and Rheometry – Part Two, Viscoelectricity’ and ‘Enter a New Dimension of X-ray Diffraction Analysis’. To register for either of these events, please make an enquiry using the form on this page, or visit www.malvernpanalytical.com/en/learn/events-and-training.

Upcoming Webinars for Malvern Panalytical

Malvern Panalytical has announced a series of webinars taking place in May, including ‘The Live Launch of the New Zetasizer Pro and Zetasizer Ultra’, ‘A Basic Introduction to Rheology and Rheometry PART 1 – Viscosity’, ‘Enlightening the Fcab-antigen Interaction via X-ray Crystallography & Solution Studies’, ‘Get the best of both worlds: Coupling advanced multi-detection with UPLC for faster and more detailed polymer analysis’, and ‘Collecting X-ray Powder Diffraction Data: How to Choose the Best Configuration and Measurement Parameters’.

Upcoming Webinars for Malvern Panalytical in April

Malvern Panalytical has announced three webinars in April: ‘X-ray Characterisation of Catalysts’, ‘Get the Best of Both Worlds’, and ‘TerraSpec® Halo Best Practices, Tips & Tricks’.

Solving Structure from Powder XRD Data

Understanding the make-up of crystalline structures is a vital aspect of the characterisation of new compounds, and can be regarded as an important first step towards the possibility of tailoring its properties.

Malvern Presents Webinar on Multi-Detection SEC

A new webinar by Malvern evaluates and discusses size-exclusion chromatography (SEC) data to see the impact of different formulations on monoclonal antibodies and biosimilar molecules.

Malvern to Host Two New Webinars in March

Malvern has announced two upcoming webinars this month: Differential scanning calorimetry (robust and powerful physical characterisation of therapeutic protein products) and Cement (composition, structure, and fineness - we are stronger together!).

NanoChOp Project Highlights Value of NanoSight

Researchers working on the European Metrology Research Project NanoChOp (Chemical and Optical Characterisation of Nanomaterials in Biological Systems), funded by EURAMET, have concluded the NanoSight Nanoparticle Tracking Analysis system offers a unique insight into the behaviour of nanoparticles in biological systems.

Malvern Extends Application of NanoSight

Malvern has highlighted its ongoing commitment to extending and supporting the application of NanoSight, a nanoparticle characterisation technology with unique capabilities, by releasing new software and expanding the global technical specialist team.

NanoSight NTA System Boosts Characterisation Toolkit

Particle Characterization Laboratories director William Bernt has highlighted the impact of adding a Malvern NanoSight nanoparticle tracking analysis (NTA) system to the toolkit for nanoparticles.

Malvern Launches OMNISEC GPC / SEC Platform

Malvern has launched a new gel permeation / size exclusion chromatography (GPC / SEC) platform, which delivers high performance and productivity for analytical laboratories.

Malvern on Publication of 1,000th Peer-Reviewed Paper to Cite NanoSight’s Nanoparticle Tracking Analysis, NTA

Malvern Instruments reports on the publication of the 1,000th peer-reviewed paper to cite the company's NanoSight Nanoparticle Tracking Analysis, NTA. Entitled 'Fumed Silica Nanoparticle Mediated Biomimicry for Optimal Cell-Material Interactions for Artificial Organ Development', it was authored by the research team of professor Alexander Seifalian from University College London.

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