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Malvern Panalytical

Drug Development Technologies

Safe, effective medicines can change the world for the better. Malvern Panalytical collaborates with our customers, applying our bespoke blend of analytical expertise and in-house contract development and manufacturing services to help you make these products efficiently and cost-effectively.

Safe, effective medicines can change the world for the better. Malvern Panalytical collaborates with our customers, applying our bespoke blend of analytical expertise and in-house contract development and manufacturing services to help you make these products efficiently and cost-effectively.

When you build on firm foundations you create high-performing products with absolute confidence. Our technologies and experts answer the scientific ‘whys’ and ‘hows’, to ensure even the smallest detail is just right, while reducing risk, saving time, and avoiding costly errors.

Need to accelerate the latest blockbuster drug to market? Worried about selecting the best method to ensure quality control for a critical vaccine? Weighed down by a challenging product formulation problem? We’ll work with you, in the way that best fits your processes and needs, to develop the right way forward.

This is the power of Malvern Panalytical. Insightful, informed, and integrated support for pharmaceutical product development and manufacture. We deal with the details so you can deliver the medicines our world needs.

The Mastersizer is the world’s most widely used particle sizing instrument for rapid and reliable particle size measurement. It is the instrument of choice for thousands of companies and research institutes.
Zetasizer measures particle and molecule size using dynamic light scattering, zeta potential and electrophoretic mobility.
Archimedes uses the technique of resonant mass measurement to detect, accurately count and reliably measure their buoyant mass, dry mass and size.
Insitec systems deliver the online continuous particle size analysis needed for efficient, cost-effective monitoring and control of industrial processes.
Kinexus brings a new dimension to ease-of-use for complex rheological measurements by providing a standard operating procedure.
Morphologi measures the particle size and shape of dry powders, particulates on membrane filters and suspensions.
Spraytec measures spray particle and droplet size distributions in real-time for more efficient product development of sprays and aerosols.
Viscosizer is an innovation in automated viscosity measurement and molecular sizing using very small sample volumes.
Viscotek GPC / SEC systems provide solutions for all applications in the protein and polymer fields.

Analysis of materials for development and manufacturing of drugs

Malvern Panalytical’s instruments are deployed across the pharmaceutical industry for discovery, development and manufacturing applications. Whether developing new, ground-breaking drugs or generic formulations, both the time and cost associated with pharmaceutical development is significant. In addition, work-flow efficiencies may be achieved when these tools are used in conjunction with each other.

Malvern Panalytical is focused on providing well-designed, innovative analytical instruments, which follow the quality by design (QbD) ethos in the fields of drug discovery, chemical and formulation development, and pharmaceutical manufacturing.

The company understands what is involved in the development and manufacturing of a drug product and the requirements to measure the critical material attributes (CMA), as well as critical quality attributes (CQA) affecting the critical process parameters (CPP) in the manufacturing process.

Molecule discovery tools

High throughput screening of large libraries of chemical compounds is the dominant technique used in early stage drug discovery, with dynamic light scattering being the optimum tool.

Being able to measure very small particle size at low concentrations, it is ideally suited as a screening tool for identifying even small levels of aggregation and potential inhibition.

Molecule optimisation with laser diffraction

In order to monitor efficacy of the suspension accurately, administering trial drug candidates in this form requires accurate, repeatable and validatable control of the active ingredient’s particle size, often on limited sample volumes.

Laser diffraction is the best tool to meet these pre-formulation requirements. This technique provides particle size distribution of nano-scale material, while also having a wide dynamic range.

Chemical development for drug delivery

When characterising bioavailability or bioequivalence of nasally administered drugs, in support of new drug applications (NDAs) or abbreviated new drug applications (ANDAs), for nasal aerosols and sprays, the US Food and Drug Administration (FDA) recommends several tests.

In cases where the active component or components are suspensions, one important attribute is the drug particle size distribution. A laser diffraction system fit for this purpose must be able to rapidly measure obscuration (optical concentration), in addition to changes in droplet size distribution and span in real-time over the life of a single actuation from the drug delivery device.

Formulation development of drugs

The size of a liposomal vesicle plays a pivotal role in the pharmacokinetic and pharmacodynamics attributes of chemotherapeutic drugs, with the liposome acting as a carrier of the drug to the site of action and dynamic light scattering can be an effective technique.

Triple-detection size exclusion chromatography (TD-SEC) can accurately characterise polymer excipient molecular size and weight and avoid incorrect determination. The conditions of a tablet coating process can be simulated using a rotational rheometer system.

The viscosity of the liquid coating is measured initially under low stress conditions to quantify its full structure, then at high shear rates to simulate spraying, and again at low stress conditions to assess the viscosity rebuild with time.

Online particle analysis for drug manufacturing

Granulation can improve the ease of handling of powder blends and prevents the segregation of fine constituents, improving consistency in subsequent process steps, principally tableting.

To improve the efficiency of the milling operation, and deliver more consistent milled particle sizes, online particle-size analysis is a solution for continuous milling monitoring and control. In addition, measurements made by the online analyser can control the process through a closed loop with the mill’s programmable logic controller (PLC).

Founded in the late-1960s as Malvern Instruments, Malvern Panalytical is now one of the world’s leading materials and biophysical characterisation companies.

Having built on a long-established reputation for innovation in particle sizing, the company today is highly respected for its technology and applications leadership in areas that range from particle, protein and macromolecule characterisation through to rheological properties measurement and into process optimisation.

Malvern Panalytical understands that when a customer chooses to invest in a Malvern Panalytical product, that customer is making a serious financial commitment. The company takes this seriously, and strives to ensure that the customer is reminded that they will receive exceptional and personalised support for the many years they will have Malvern Panalytical equipment.

Please contact Malvern Panalytical with your business enquiry.

Zetasizer Advance – Light Scattering for Every Application

The Zetasizer Advance range offers particle size, particle charge (zeta potential) and molecular weight analysis as well as advances such as adaptive correlation, M3-PALS zeta analysis, constant current zeta mode and a data quality advice software.

OMNISEC – Advanced Multi-Detector GPC/SEC System

OMNISEC is a Gel Permeation Chromatography (GPC) / Size Exclusion Chromatography (SEC) system for the measurement of absolute molecular weight, molecular size, intrinsic viscosity, branching and other parameters.

Pharmaceutical Challenges Aided by Laboratory Powder X-ray Diffraction

This white paper explores a number of ways that today's modern, laboratory-based powder x-ray diffraction (PXRD) instrumentation and advanced software can greatly assist pharmaceutical scientists in their quest to develop high-quality, stable products and accelerate their speed-to-market.

Getting Acquainted with the XRF Theory

This white paper provides a general introduction to X-ray Fluorescence (CRF) spectrometry and XRF analysis. It explains how a spectrometer works and how XRF analysis is achieved. 

Malvern Panalytical and Concept Life Sciences Announce Integration

Malvern Panalytical, manufacturer of analytical systems, and Concept Life Sciences (CLS), a contract research organisation, have today announced a full business integration. The integration will expand Amplify Analytics, the companies' existing analytical instrument and service relationship, to include CLS's chemistry and biology services. Both entities are operating businesses within the Spectris Group.

13 April 2021

Aeris: All New Compact XRD System

Malvern Panalytical is pleased to announce the launch of an innovative version of its Aeris compact X-ray diffractometer (XRD).

25 February 2021

2020 Forthcoming Events

Below are the forthcoming shows that will exhibit Malvern’s pharmaceutical solutions in 2020.

1 July 2020

Contract Research Services

We recognise that the data our analytical systems give to our clients is critical for informing the development of innovative products or guaranteeing product quality is preserved during manufacture.

7 April 2020

Unlocking the Power of Expert Analytics

Malvern Panalytical (Malvern, UK) and Concept Life Sciences (Cheshire, UK) have launched a new partnership that combines advanced instrumentation with expert analytical services for discovery and development.

31 March 2020

Pharmaceutical Drug Development and Particle Sizing

Typically, when an individual is suffering from minor ailments at home, such as a headache, heartburn or a common cold, medications such as paracetamol, indigestion liquid and cold remedies are used in an attempt to alleviate symptoms. However, the reliability of these products can sometimes be questionable.

8 August 2019

Malvern Panalytical to Host Webinars this Month

Malvern Panalytical has announced its next round of webinars. Find out more below. If you are interested in attending any of these events, please send an enquiry to find out how to register. 

2 July 2019

Malvern Panalytical Announces New Webinars for November

Malvern Panalytical has announced the next set of webinars for the November and December period, including a particle size masterclass, ‘Using Rheology to Characterise Asphalt for Roofing Applications’ and 'Major Advancement in the Elemental Analysis of Metal Sulfides'. If you are interested in attending any of these events, please make an enquiry using the form on this page. 

2 November 2018

Malvern Panalytical’s Latest Seminars

Malvern Panalytical has announced its latest set of seminars for the November/December period, including a NanoSight workshop, an OMA user day and a DLS Workshop. If you are interested in attending any of the events or have any questions, please make an enquiry using the form on this page.

30 October 2018

Malvern Panalytical Announces Next Batch of Seminars

Malvern has announced a series of seminars taking place throughout September and October. If you are interested in attending any of the events and have any questions, please make an enquiry using the form on this page.

12 September 2018

Characterising the Size and Concentration of Liposomes

Liposomes are nowadays frequently used as drug delivery systems, and as such requires that they are well characterised for manufacturing and batch release. This characterisation includes their size and size distribution.

7 August 2018

Malvern Panalytical’s July Webinars

Malvern Panalytical has announced a wide range of upcoming webinars throughout July, including ‘Enter a New Dimension of X-Ray Diffraction Analysis’ and ‘Applications of Light Scattering and Intrinsic Viscosity Detectors with Size Exclusion Chromatography SEC in Characterising Biopharmaceutical and Other Polymers’. To register for any of these webinars, please either make an enquiry using the form on this page or visit www.malvernpanalytical.com/en/learn/events-and-training/webinars.

9 July 2018

Upcoming Malvern Panalytical Seminars

Malvern Panalytical has announced it will be hosting a number of seminars, including ‘One-on-One Breakfast Catch-up on the Latest Powder XRD’, ‘XRF Demonstration (Singapore)’ and ‘Pharma & Food Sector Seminar’.

13 June 2018

Malvern Panalytical’s June Webinars

Malvern Panalytical has announced some key webinars taking place this month, including ‘A Basic Introduction to Rheology and Rheometry – Part Two, Viscoelectricity’ and ‘Enter a New Dimension of X-ray Diffraction Analysis’. To register for either of these events, please make an enquiry using the form on this page, or visit www.malvernpanalytical.com/en/learn/events-and-training.

6 June 2018

Upcoming Webinars for Malvern Panalytical

Malvern Panalytical has announced a series of webinars taking place in May, including ‘The Live Launch of the New Zetasizer Pro and Zetasizer Ultra’, ‘A Basic Introduction to Rheology and Rheometry PART 1 – Viscosity’, ‘Enlightening the Fcab-antigen Interaction via X-ray Crystallography & Solution Studies’, ‘Get the best of both worlds: Coupling advanced multi-detection with UPLC for faster and more detailed polymer analysis’, and ‘Collecting X-ray Powder Diffraction Data: How to Choose the Best Configuration and Measurement Parameters’.

3 May 2018

Upcoming Webinars for Malvern Panalytical in April

Malvern Panalytical has announced three webinars in April: ‘X-ray Characterisation of Catalysts’, ‘Get the Best of Both Worlds’, and ‘TerraSpec® Halo Best Practices, Tips & Tricks’.

13 April 2018

Solving Structure from Powder XRD Data

Understanding the make-up of crystalline structures is a vital aspect of the characterisation of new compounds, and can be regarded as an important first step towards the possibility of tailoring its properties.

11 July 2017

Malvern Presents Webinar on Multi-Detection SEC

A new webinar by Malvern evaluates and discusses size-exclusion chromatography (SEC) data to see the impact of different formulations on monoclonal antibodies and biosimilar molecules.

26 April 2017

Malvern to Host Two New Webinars in March

Malvern has announced two upcoming webinars this month: Differential scanning calorimetry (robust and powerful physical characterisation of therapeutic protein products) and Cement (composition, structure, and fineness - we are stronger together!).

7 March 2017

NanoChOp Project Highlights Value of NanoSight

Researchers working on the European Metrology Research Project NanoChOp (Chemical and Optical Characterisation of Nanomaterials in Biological Systems), funded by EURAMET, have concluded the NanoSight Nanoparticle Tracking Analysis system offers a unique insight into the behaviour of nanoparticles in biological systems.

4 March 2016

Malvern Extends Application of NanoSight

Malvern has highlighted its ongoing commitment to extending and supporting the application of NanoSight, a nanoparticle characterisation technology with unique capabilities, by releasing new software and expanding the global technical specialist team.

11 December 2015

NanoSight NTA System Boosts Characterisation Toolkit

Particle Characterization Laboratories director William Bernt has highlighted the impact of adding a Malvern NanoSight nanoparticle tracking analysis (NTA) system to the toolkit for nanoparticles.

2 November 2015

Malvern Launches OMNISEC GPC / SEC Platform

Malvern has launched a new gel permeation / size exclusion chromatography (GPC / SEC) platform, which delivers high performance and productivity for analytical laboratories.

28 January 2015

Malvern on Publication of 1,000th Peer-Reviewed Paper to Cite NanoSight’s Nanoparticle Tracking Analysis, NTA

Malvern Instruments reports on the publication of the 1,000th peer-reviewed paper to cite the company's NanoSight Nanoparticle Tracking Analysis, NTA. Entitled 'Fumed Silica Nanoparticle Mediated Biomimicry for Optimal Cell-Material Interactions for Artificial Organ Development', it was authored by the research team of professor Alexander Seifalian from University College London.

15 April 2014

Denmark

Malvern Panalytical Nordic Filial af Malvern Panalytical Nordic AB
Skodsborgvej 307
Naerum
DK-2850
Denmark

Finland

Malvern Panalytical B.V. Branch Finland
Hosmed Oy
Ennekuja 1
FI-02270 Espoo
Finland

France

Malvern Panalytical
Bâtiment Le Phénix 1
24 Rue Émile Baudot
Palaiseau
91120
France

Germany

Malvern Panalytical GmbH
Nürnberger Str. 113
Kassel
34123
Germany

India

Malvern Aimil Instruments Pvt Ltd BSEL Tech Park
11th floor Sector - 30A
Opp Vashi Railway Station
Vashi
Navi Mumbai 400 705
Mumbai
India

Japan

North Bldg 511 Kobe International Business Center
5-5-2 Minatojimaminami-machi Chuo-ku
Kobe-shi
Hyogo Prefecture 650-0047
Honshu
Japan

Korea

Malvern Panalytical, a division of Spectris Korea Ltd.
7F SH Energy B/D
16-6 Sunae-Dong
Bundang-Gu, Seongnam-City
Kyeonggi-Do, Seoul
South Korea

Mexico

Malvern Panalytical, a division of Spectris Mexico S. de R.L. de C.V.
Av. Pedro Ramirez Vazquez 200-13 Nivel 1, col. Valle Oriente
San Pedro Garza Garcia, Nuevo Leon
CP 66269
Mexico

Norway

Malvern Panalytical Nordic AB
Lokkeasveien 22A
N-3138 Skallestad
Vestfold
Norway

Sweden

Malvern Panalytical Nordic AB
Vallongatan 1
752 28 Uppsala
Uppsala County
Sweden

USA

Malvern Panalytical Inc.
2400 Computer Drive, Suite 2100
Westborough
MA 01581
United States of America

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