Malvern Panalytical has announced the Morphologi range, consisting of Morphologi 4 and Morphologi 4-ID.

Built on the success of previous systems, the 2018 iF design award-winning Morphologi 4 and Morphologi 4-ID offer uniquely powerful tools for the rapid, automated component-specific measurement of particle size, shape and chemical composition.

They deliver substantial improvements in measurement speed, image definition and the range of materials that can be successfully analysed. Offering sharper and faster particle size and shape measurements, the instruments add value to product development, troubleshooting and quality control (QC), particularly in analytical environments where a deeper understanding of a process and sample is required, such as during the development and processing of pharmaceuticals, metal powders and battery materials.

The Morphologi 4 is a fully automated system for characterising particles ranging in size from less than one micron up to 1mm. Compared to its predecessor, it offers quicker measurement, with a time saving of around 25%, while delivering simpler, more intuitive method development and greater particle definition.

A key feature is Sharp Edge, a new automated segmentation / thresholding algorithm that makes it easier to detect and define particles. Measurement sensitivity is further boosted by the 18-megapixel camera and by the enclosure of the sample during imaging.

These advances make it possible to accurately measure light-sensitive and low-contrast samples, such as proteins and certain mineral and chemical species, as well as deliver enhanced shape parameter sensitivity for all types of sample. This makes it possible to detect the subtle differences that are essential for rigorous process and product optimisation and robust supply chain management.

The Morphologi 4-ID delivers Morphologically-Directed Raman Spectroscopy (MDRS®), integrating the static imaging capabilities of the Morphologi 4 with Raman spectroscopy to enable the component-specific morphological characterisation of different chemical specimens in a blend.

Offering significantly faster spectral acquisition times than the previous model, with a time reduction of up to 80%, it also allows acquisition conditions to be customised to the sample.

This enhanced control, combined with an extended spectral range, maximises the range of materials that can be identified and/or differentiated within a mixture. The instrument is fully automated and is designed to allow both particle characterisation scientists with limited spectroscopy experience, and more experienced spectroscopists to gain an in-depth understanding of their particulate samples.

Product manager for analytical imaging at Malvern Panalytical Deborah Huck-Jones comments: “These latest additions to Malvern Panalytical’s range of advanced analytical characterisation technologies deliver greater detail in faster measurement times than ever before.

“Their applications in innovator and generic pharmaceutical development support the critical goal of speed to market.  A particular benefit of MDRS to generics formulators is its ability to help demonstrate Q3 bioequivalence in-vitro by ensuring the required physicochemical attributes of particles in the test formulation match those of the reference formulation, thus reducing or eliminating the need for clinical endpoint studies.”

Associate product manager for analytical imaging at Malvern Panalytical Cathryn Langley adds: “In many industrial applications, a specification based on size alone is no longer adequate. The flow and packing properties of metal powders and electrode materials, for example, are governed by particle shape, as well as size.

“This means that both parameters must be controlled to optimise performance, such as the properties of a finished injection-moulded component, or the power and discharge characteristics of a battery.

“The new Morphologi systems make it quicker and easier to access accurate and component-specific particle size and shape data to develop a deeper understanding of such products, and of how to optimise and control their routine manufacture.”