Sartorius has implemented specialized algorithms for the scaling and combination phases based on physical principles rather than intuitive and empirical procedures. We describe the conceptualization of a database and software application, the Extractables Simulator (ExSim).
Sartorius is one of the world’s leading providers of laboratory and process technologies and equipment.
Its innovative products and high-quality services help customers worldwide implement complex and quality-critical processes in biopharmaceutical production and laboratory environments in a time and cost-efficient way. The company’s key customers are from the biotech, pharmaceutical, and food industries, as well as from public research institutes and laboratories.
Sartorius operates its own production facilities in Europe, Asia, and America, as well as sales offices and local representatives in more than 110 countries. The company is dedicated to its philosophy of “Turning science into solutions” every single day.
Bioreactors and fermentors
Sartorius Stedim Biotech supplies a wide range of bioreactors and fermentors for lab, pilot, and process-scale applications. The BIOSTAT® product series includes single-use, autoclavable, and in-situ sterilisable systems.
Configurable single-use systems for biomanufacturing
Sartorius’ FlexAct® configurable single-use systems enable you to custom-configure single-use solutions for entire biomanufacturing steps such as buffer preparation (BP), cell harvest (CH), virus inactivation (VI), media preparation (MP) and virus removal (VR).
The configurable single-use systems offer a large variety of configuration options and allow for complete control of practically any step in upstream and downstream processing.
Liquid filters for the pharma industry
Liquid filters are available in several designs, including sterile filters, prefilters, and membrane filters. Sartorius’ filter capsules and filter cartridges are suitable for several applications from screening in cell harvest and clarification to bioburden and particle reduction.
Filter integrity testing systems
Filter integrity testing is an essential procedure to detect defective filter cartridges and prevent their use. Sartorius’ Sartocheck® family offers solutions for all customer needs. Different devices and a comprehensive accessory package allow the highest flexibility in filter integrity testing.
Single-use bioprocess bags
Sartorius offers single-use bioprocess bags for the preparation, storage, and transport of biopharmaceutical solutions, intermediates, and final bulk products. Also available is a complete range of aseptic transfer bags for the aseptic transfer of components into clean rooms, isolators, or restricted access barrier systems (RABS), as well as for contained transfer of potent powders.
Single-use bio process bags from Sartorius Stedim Biotech provide a disposable alternative to traditional glass, stainless steel, and rigid plastic carboys.
Membrane chromatography units
Membrane chromatography for the chromatographic purification of proteins and vaccines from complex mixtures is a key process step in pharmaceutical production to ensure high purity and high yield.
Sartorius membrane adsorbers allow much faster flow rates than conventional columns, resulting in 75% time savings and typically 80% to 90% reduced buffer consumption. Membrane chromatography capsules are easy and convenient to use to advance your everyday work.
Containers and rack systems and drug delivery systems
Sartorius provides containers and rack systems for the storage and processing of biopharmaceutical fluids, fluid management control in the biopharmaceutical process, or the secure and convenient shipment of sterile bulk pharmaceutical fluids. Drug delivery systems are ready-to-use and suitable for the preparation of total parenteral nutrition, among other applications.
Sartorius provides laboratory balances for professional weighing, including ultra-microbalances, microbalances, analytical balances, precision balances, and gold and carat balances, which excel in speed and accuracy, manufactured with years of experience in mechatronics.
Lab water systems
Lab water systems are suited for routine applications like washing or flushing of laboratory equpiment as well as for critical applications that require ultra-pure water. They also can be utilised for atomic absorption, ion chromatography, or the preparation of buffers, media, and reagents.
Sartorius’ lab water systems are split into type 1 or type 2 ultra-pure, reverse osmosis, and water softening systems so they cover the complete demand for lab water.
The Sartorius product range also includes ultrafiltration devices for protein concentration and buffer exchange in laboratory scale. All product groups have unique features to be optimally equipped for the main applications in their volume range. Furthermore, you can choose between various ultrafilter membrane discs for sample concentration, such as in stirred cells.
Sartorius offers various chromatography devices such as spin columns, capsules, multiwell plates and strips, vacuum manifolds and syringe filter units or membranes. Typical applications are concentration, purification and desalting of peptides, polishing, flow-to-waste and analyte collection, protein purification and sample preparation.
Chromatography devices with ion exchange, metal chelate, Protein A and G, Anti-HSA and C18 matrices offer a comprehensive portfolio for protein capture and purification.
The Sartorius Group is a leading international partner of life science research and the biopharmaceutical industry. With innovative laboratory instruments and consumables, the Group’s Lab Products & Services Division concentrates on serving the needs of laboratories performing research and quality control at pharma and biopharma companies and those of academic research institutes.
The Bioprocess Solutions Division with its broad product portfolio focusing on single-use solutions helps customers to manufacture biotech medications and vaccines safely and efficiently. The Group has been annually growing by double digits on average and has been regularly expanding its portfolio by acquisitions complementary technologies.
In fiscal 2020, the company earned sales revenue of some 2.34 billion euros. At the end of 2020, nearly 11,000 people were employed at the Group’s approximately 60 manufacturing and sales sites, serving customers around the globe.
Sanofi’s key driver for this study was to reduce the operating costs of existing purification steps with high resin costs. Regulatory concerns were to be tested by determining product quality consistency through process transfer and scale-up. The feasibility of extended purifications at production scale was also determined by evaluating BioSMB system robustness.
When designing a weighing chamber, there are many regulatory requirements, which must be taken into consideration.
Stoppers for pharmaceutical primary packaging must preserve the safety and efficacy of injectable drugs.
Sartorius has expanded its biopharmaceutical manufacturing facility Sartorius Stedim Campus, which is located in Yauco, Puerto Rico, US.
The latest Sartorius’ research forum Xchange focused on promoting interdisciplinary cooperation between science and industry in regards to regenerative medicine and cell therapy.
Sartorius Stedim Biotech’s (SSB) ambr® 15 automated micro bioreactor system is combined with a Nova Biomedical (Nova) BioProfile® FLEX2 automated cell culture analyser, and was shown for the first time at the Cell Line Development & Engineering Conference in San Diego, California.
Sartorius has announced the opening of its new 25,000m² facility for the manufacture of laboratory instruments in the industrial zone of Grone in Goettingen.
SSB Subsidiary Offers Advanced Stedium Dashboard 2 Software Solution Delivering Insight into Manufacturing Process Performance
Sartorius Stedim Biotech (SSB) has launched the Active Dashboard 2, an advanced software solution.
Sartorius Stedim Biotech (SSB) has announced BioOutsource's new microsite will detail Sartorius Stedim Cellca's cell line and upstream process development services.
The amblr® 250 modular bioreactor system is an expandable benchtop workstation, which offers a simple approach to process development for fermentation and cell culture.