4D-125 is under clinical development by 4D Molecular Therapeutics and currently in Phase II for Retinitis Pigmentosa (Retinitis). According to GlobalData, Phase II drugs for Retinitis Pigmentosa (Retinitis) have a 58% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how 4D-125’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
4D-125 overview
4D-125 is under development for the treatment of X-linked retinitis pigmentosa. The therapeutic candidate is administered through intravitreal route into the retina. It is being developed based on vector evolution platform technology that uses adeno-associated virus (AAV) R100 vector.
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4D Molecular Therapeutics overview
4D Molecular Therapeutics is a gene therapy company that discovers and develops targeted and proprietary AAV gene therapy vectors and therapeutic products. The company’s pipeline products include 4D-125, 4D-110, 4D-150, 4D-135, 4D-310 and 4D-710. It has developed a technology platform, Therapeutic Vector Evolution that empowers to creation of customized gene delivery vehicles (novel AAV vectors) to deliver genes to any tissue or organ in the body. 4D Molecular Therapeutics develops pipeline products that target therapeutic areas such as the liver, retina, heart, brain, skeletal muscle, and lung, among others. The company works in partnership with F. Hoffmann-La Roche Ltd to design, develop and commercialize AAV products for use in ophthalmology indications. 4D Molecular Therapeutics is headquartered in Emeryville, California, the US.
For a complete picture of 4D-125’s drug-specific PTSR and LoA scores, buy the report here.
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