ABBVCLS-484 is under clinical development by Calico Life Sciences and currently in Phase I for Non-Small Cell Lung Cancer. According to GlobalData, Phase I drugs for Non-Small Cell Lung Cancer have an 82% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how ABBVCLS-484’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

ABBVCLS-484 overview

ABBVCLS-484 is under development for the treatment of solid tumor, head and neck squamous cell carcinoma (HNSCC), non-small cell lung cancer (NSCLC) and clear cell renal cell carcinoma. It is administered through oral route as capsule. It acts by targeting tyrosine-protein phosphatase non-receptor type 2 (PTPN2). It was also under development for the treatment of gastric cancer and adenocarcinoma of the gastroesophageal junction.

Calico Life Sciences overview

Calico Life Sciences (Calico) is a research and development company. It is operating its business as Calico Group LLC, is a life extension research and development company. It focusses on the discovery, development, and commercialization of therapies for the treatment of diseases of aging including neurodegeneration and cancer. It is focusing on both basic research and the translation of our discoveries into new interventions that can help people live healthier, and maybe longer, lives. It also engaged in research of advanced technologies to increase understanding of the biology that controls lifespan. Calico is headquartered in South San Francisco, California, the US.

For a complete picture of ABBVCLS-484’s drug-specific PTSR and LoA scores, buy the report here.


GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.