Adavosertib is under clinical development by AstraZeneca and currently in Phase II for Relapsed Acute Myeloid Leukemia. According to GlobalData, Phase II drugs for Relapsed Acute Myeloid Leukemia have a 21% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Adavosertib’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Adavosertib (AZD-1775, MK-1775) is under development for the treatment of advanced refractory lymphoma and multiple myeloma, advanced solid tumors including head and neck squamous cell carcinoma, advanced and metastatic pancreatic adenocarcinoma, hypopharyngeal cancer, laryngeal cancer, oropharyngeal cancer, oral cancer, cervical cancer, vaginal cancer, recurrent endometrial cancer, metastatic triple negative breast cancer(as a second and third line therapy), relapsed and refractory acute myeloid leukemia, myelodysplastic syndrome,definitive chemoradiation esophageal and gastroesophageal junction cancer, small-cell lung cancer and platinum-resistant TP53-mutated fallopian tube and primary peritoneal cancer, metastatic colorectal cancer and adenocarcinoma of the pancreatic cancer. It is a small molecule administered orally in the form of capsule. It acts by targeting Wee1. It was also under development for the treatment of non-squamous non-small-cell lung cancer. The drug candidate is a new molecular entity (NME).
It was under development for head and neck cancer, esophageal cancer and gastric cancer, epithelial ovarian, uterine cancer and solid tumors.
AstraZeneca is a biopharmaceutical company, which is focused on discovery, production and commercialization of a range of prescription drugs. It develops products related to therapy areas such as respiratory, cardiovascular, renal and metabolic diseases, cancer, autoimmune, infection and neurological diseases. The company’s product portfolio includes biologics, prescription pharmaceuticals and vaccines. AstraZeneca sells its products through wholly-owned local marketing companies, distributors and local representative offices. The company markets its products to primary care and specialty care physicians. The COVID-19 Vaccine AstraZeneca has been approved for conditional marketing or emergency use. The company operates in Europe, the Americas, Asia, Africa and Australasia. AstraZeneca is headquartered in Cambridge, Cambridgeshire, the UK.
For a complete picture of Adavosertib’s drug-specific PTSR and LoA scores, buy the report here.