Aldoxorubicin is under clinical development by ImmunityBio and currently in Phase II for Colorectal Cancer. According to GlobalData, Phase II drugs for Colorectal Cancer have a 25% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Aldoxorubicin’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Aldoxorubicin overview

Aldoxorubicin (INNO-206, DOXO-EMCH, doxorubicin-EMCH) is under development for the treatment of solid tumors including advanced soft tissue sarcoma, triple-negative breast cancer, metastatic pancreatic cancer, metastatic small cell lung cancer (SCLC), glioblastoma multiforme and ovarian cancer and advanced squamous cell carcinoma (SCC) as head and neck or non-small cell lung cancer, relapsed and refractory colorectal cancer. The drug candidate is administered as an intravenous infusion. The drug candidate targets DNA synthesis. Aldoxorubicin is a tumor-targeted doxorubicin conjugate. The drug candidate is a (6-Maleimidocaproyl) hydrazone of doxorubicin. It is based on conjugated tumor-targeted technology. INNO-206 is a chemically modified version of doxorubicin that incorporates an acid sensitive linker technology to improve targeting to the tumor.

It was also under the development for the treatment of kaposi sarcoma, metastatic pancreatic ductal adenocarcinoma, bone cancer including rhabdomyosarcoma, Ewing's sarcoma and mixed mesodermal sarcoma), chondrosarcoma or osteosarcoma of intermediate or high grade, gastrointestinal stromal tumors.

ImmunityBio overview

ImmunityBio, a subsidiary of NantWorks LLC, is a clinical-stage biotechnology company developing therapies for therapies for cancer and infectious diseases. The company product pipeline includes anktiva + BCG, anktiva + keytruda (pembrolizumab), aldox + anktiva + PD-L1 t-hank, anktiva + tri-ad5 vaccines, anktiva + bevacizumab + PD-L1 t-hank, anktiva + IBRX-042 vaccination, anktiva + M-ceNK and anktiva + CD19 t-haNK. ImmunityBio pipeline candidates treat bladder cancer, lung cancer, lynch syndrome, pancreatic cancer, glioblastoma, HPV, advanced Solid tumors, non-hodgkin lymphoma and HIV. The company operates in Italy, South Korea and the US. ImmunityBio is headquartered in San Diego, California, the US.

For a complete picture of Aldoxorubicin’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 7 February 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.