Allogene Therapeutics. has been granted a patent for constitutively active chimeric cytokine receptors (CACCRs) that enhance the activation, proliferation, and potency of CAR-bearing immune cells. The patent details the structure and composition of these receptors, including specific amino acid sequences and substitutions. GlobalData’s report on Allogene Therapeutics gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Allogene Therapeutics, Cytokine activate T-cell based compositions was a key innovation area identified from patents. Allogene Therapeutics's grant share as of June 2024 was 7%. Grant share is based on the ratio of number of grants to total number of patents.
Constitutively active chimeric cytokine receptors for immune cell enhancement
The patent US12043655B2 describes a novel constitutively active chimeric cytokine receptor (CACCR) designed to enhance immune responses, particularly in engineered immune cells such as T-cells. The CACCR is composed of two monomers, each featuring a transmembrane domain, a Janus Kinase (JAK)-binding domain, and a recruiting domain. The design includes specific amino acid sequences and substitutions that facilitate the receptor's dimerization and functionality. The claims detail various configurations of the JAK-binding and recruiting domains, allowing for flexibility in the receptor's design, including the potential to recruit signaling proteins from multiple cytokine receptors.
Additionally, the patent outlines methods for creating engineered immune cells that express the CACCR alongside chimeric antigen receptors (CARs). This dual expression aims to improve the efficacy of immune cells in targeting and treating cancers, including both solid and liquid tumors. The patent also covers the development of expression vectors, such as lentiviral vectors, to introduce the necessary polynucleotides into immune cells. Furthermore, it includes claims for pharmaceutical compositions and kits containing these engineered immune cells, emphasizing their therapeutic potential in cancer treatment.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
