Amgen had 14 patents in artificial intelligence during Q3 2023. Amgen Inc has filed a patent for a method of controlling a cell culture process. The method involves obtaining current values of cell culture attributes, predicting future values of a particular attribute, and controlling physical inputs to the process. This is done by using a data-driven predictive model and a model predictive controller. GlobalData’s report on Amgen gives a 360-degreee view of the company including its patenting strategy. Buy the report here.

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Amgen grant share with artificial intelligence as a theme is 21% in Q3 2023. Grant share is based on the ratio of number of grants to total number of patents.

Recent Patents

Application: Predictive modeling and control of cell culture (Patent ID: US20230272331A1)

Amgen Inc. has filed a patent for a method of controlling a cell culture process. The method involves obtaining current values of cell culture attributes, predicting future values of a particular cell culture attribute, and controlling physical inputs to the cell culture process. The prediction is made using a data-driven predictive model that takes into account historical data. The physical inputs are controlled using a model predictive controller.

The patent claims provide further details about the method. Claim 1 specifies that the current values of cell culture attributes can be obtained through manual sampling or simulation. The future values are predicted by applying the current values and an earlier value of at least one attribute to a data-driven predictive model. The physical inputs are controlled by applying the future values to a model predictive controller.

Claim 2 states that the data-driven predictive model can be a regression model. Claim 3 explains that the current values are obtained during a current time interval, and the prediction of future values includes using the current value, a value from a previous time interval, and a value from a second previous time interval as inputs to the predictive model.

Claim 4 adds that the method can include obtaining additional current values and predicting additional future values for one or more additional time intervals. These additional values can be used as inputs to a different regression model.

Claim 5 introduces the possibility of using a neural network as the data-driven predictive model, and claim 6 specifies that it can be a feedforward neural network.

Claim 7 describes obtaining the current values of cell culture attributes using Raman spectroscopy measurements. Claim 8 lists examples of cell culture attributes, such as metabolite levels, viable cell density, total cell density, viability, and added feed volume.

Claim 9 mentions the prediction of future values for multiple days. Claim 10 specifies that one of the physical inputs that can be controlled is the amount of glucose introduced into the cell culture.

The patent also includes claims related to computer-readable media storing instructions for implementing the method and a system comprising a bioreactor, input devices, analytical instruments, and a computing system for controlling the cell culture process.

In summary, the patent filed by Amgen Inc. describes a method of controlling a cell culture process by obtaining current values of cell culture attributes, predicting future values using a data-driven predictive model, and controlling physical inputs using a model predictive controller. The method can involve regression models or neural networks and can utilize Raman spectroscopy measurements. The patent also includes claims related to computer-readable media and a system for implementing the method.

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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.