The Angiotensinogen pipeline drugs market research report outlays comprehensive information on the Angiotensinogen targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA), and molecule type. GlobalData’s report assesses the drugs in the Angiotensinogen pipeline by therapy areas, indications, stages, MoA, RoA, molecule type and the key players in the development pipeline. Buy the report here.
The report also covers products from therapy areas such as Cardiovascular, and Metabolic Disorders which include the indications Hypertension, Resistant Hypertension, and Hypertriglyceridemia. It also reviews key players involved in Angiotensinogen targeted therapeutics development with respective active and dormant or discontinued products.
The Angiotensinogen pipeline targets constitutes close to eight molecules. Out of which, approximately eight molecules are developed by companies and the remaining by the universities/institutes. The molecules developed by companies in Phase II, Phase I, IND/ CTA Filed, Preclinical, and Discovery stages are 2, 1, 1, 3, and 1 respectively.
Angiotensinogen overview
Angiotensinogen is a protein that in humans is encoded by a gene AGT. Angiotensinogen is a precursor protein that plays a crucial role in the renin-angiotensin system (RAS), a hormonal system that regulates blood pressure, fluid, and electrolyte balance. Angiotensinogen precursor is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
For a complete picture of Angiotensinogen’s drug pipeline, buy the report here.
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