Pharmaceutical Solid-Liquid Separation Filtration Equipment
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DrM, Dr. Mueller AG

Filtration and Mixing Equipment for Pharmaceutical Solid-Liquid Separation

DrM, Dr. Mueller AG (DrM) designs and manufactures filtration equipment for solid-liquid separation in the pharmaceutical industry.

Alte Landstrasse 415,
8708 Maennedorf,
Switzerland

Alte Landstrasse 415,
8708 Maennedorf,
Switzerland



Pharmaceutical Solid-Liquid Separation

DrM, Dr. Mueller AG (DrM) designs and manufactures filtration equipment for solid-liquid separation in the pharmaceutical industry.

The company also develops vibratory mixers and single-use technologies.

From its FUNDA Filter in the 1950s, DrM established itself in the field of automatic and fully enclosed filtration tanks, later developing and patenting automated filtration processes within single-use filter bags.

DrM’s strength lies in its process experience within the filtration sector, which now extends to the pharmaceutical and biotechnology industries, with innovative decides and solutions to resolve unique process problems.

Single-use filtration for pharmaceutical applications

DrM develops patented automated filtration processes within single-use filter bags.

The company views potential in incorporating the flexibility of the bag as a process element for tasks such as heel elimination or moving liquids over the traditional view of single-use equipment as a static device.

Process intensification and scale-up

There has been a rising demand in innovative cell separation technologies as the biologics industry is shifting towards more diverse batch volumes and cell concentrations cultivated in single-use facilities. Traditional technologies, such as cross-flow filters and depth filters, have large footprints, limited flow rates, and rely on high filter areas. The latter causes a high volume of extractables and leachables while being unsustainable and causing extortionate financing and running costs.

DrM’s CONTIBAC® single-use filter overcomes such restrictions, using a cyclic cake filtration method, which gives the product’s filter unmatched speed without decreasing filtrate quality. The cyclic operation also allows filtering of the same batch volume with a smaller filter.

Using a small filter is more sustainable and significantly reduces contamination risk. Therefore, CONTIBAC® is advantageous regardless of whether a batch or continuous bioreactor is employed.

Cell culture bioprocessing

Bioprocessing of cell cultures can be divided into three consecutive steps: fermentation, harvesting and purification. Single-use filters are optimum for cell harvesting, suited for cell densities up to 50m cells / ml.

DrM’s single-use filters are complete with a multi-cycle function, enabling smaller footprints and validation and operation cost in comparison to centrifugal and depth filters.

Single-use mixers for cell homogenisation

Liquid batches filled into vials for injection must go through an effective mixing process. The heel must be disposed of promptly, as mixing cannot be guaranteed as the batch is processed and the tank drained. A mixing device that reduces this heel allows higher yields, reducing operating cost.

FUNDAMIX® single-use mixers can move large quantities of liquid without affecting sensitive proteins. Vibrations produce high degrees of random distribution at low shear effects on proteins and without baffles.

Single-use portfolio

As well as filters and mixers, DrM’s product portfolio includes a newly patented pinch valve with a hose size adaptable bed to guarantee uninterrupted operation for many cycles.

The company also developed a control panel system to allow for efficient and automatic use of its own products, as well as those of other companies.

Extended product portfolio

DrM’s non-single-use products for the life sciences industry include its FUNDABAC® technology targeted to companies that adhere to good manufacturing practice (GMP).

STERIBAC® candle filter as a unique execution of the conventional and the traditional FUNDAMIX® vibromixer also make up DrM’s extensive portfolio.

About DrM

Headquartered in Switzerland, DrM maintains subsidiaries in China, Dubai (UAE), India, Malaysia, Poland and the USA, and represented globally by licensees, representatives, sales agencies and its own sales offices.

All company mixers and filters, custom-made to suit the underlying process, can be developed on an individual basis. DrM’s quality system is the International Organisation of Standardisation (ISO) 9001 certified for the design and manufacture of plants.

Cell Harvest Using Only One Filter Per Batch

As the biologics industry is moving towards more diverse batch volumes and cell concentrations that are cultivated in single-use facilities, there has been a demand for innovative cell separation technologies.

DrM, Dr. Mueller AG

Alte Landstrasse 415

8708 Maennedorf

Switzerland

DrM Shanghai Co Ltd

Building 2


No 18 Rong Xin Road


Xinqiao, Song Jiang District


Shanghai 201612


China

DrM Polska Sp z oo

ul Toruńska 248a


87-805 Wloclawek


Poland

DrM Filter Technology Private Ltd

501 The Park

O P Road

Near Akshar Chowk

Vadodara

Gujarat 390 020

India

DrM Inc

2125 Center Ave

Suite 507


Fort Lee NJ 07024


United States of America

SL Engineering

SEA Regional Office


21 (2nd Floor),


Jalan PCR 1


Kawasan Perniagaan Cheras Raya Batu 11

Selangor 43200


Jalan Balakong Cheras


Malaysia

DrM, Dr Mueller Ltd

Swiss Tower, 20th Floor


PO Box 392394


Dubai


United Arab Emirates