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DrM, Dr. Mueller AG

Filtration and Mixing Equipment for Pharmaceutical Solid-Liquid Separation

DrM, Dr. Mueller AG (DrM) designs and manufactures filtration equipment for solid-liquid separation in the pharmaceutical industry.

Address
Alte Landstrasse 415,
8708 Maennedorf,
Switzerland
Phone

Pharmaceutical Solid-Liquid Separation

DrM, Dr. Mueller AG (DrM) designs and manufactures filtration equipment for solid-liquid separation in the pharmaceutical industry.

The company also develops vibratory mixers and single-use technologies.

From its FUNDA Filter in the 1950s, DrM established itself in the field of automatic and fully enclosed filtration tanks, later developing and patenting automated filtration processes within single-use filter bags.

Headquartered in Switzerland, DrM maintains subsidiaries in China, Dubai (UAE), India, Malaysia, Poland and the USA, and represented globally by licensees, representatives, sales agencies and its own sales offices.

All company mixers and filters, custom-made to suit the underlying process, can be developed on an individual basis. Quality is an important aspect to the manufacturing process, which is why DrM is ISO 9001 certified for the design and manufacture of plants.

DrM’s strength lies in its process experience within the filtration sector, which now extends to the pharmaceutical and biotechnology industries, with innovative decides and solutions to resolve unique process problems.

Single-use filtration for pharmaceutical applications

DrM develops patented automated filtration processes within single-use filter bags.

The company views potential in incorporating the flexibility of the bag as a process element for tasks such as heel elimination or moving liquids over the traditional view of single-use equipment as a static device.

Process intensification and scale-up

There has been a rising demand in innovative cell separation technologies as the biologics industry is shifting towards more diverse batch volumes and cell concentrations cultivated in single-use facilities. Traditional technologies, such as cross-flow filters and depth filters, have large footprints, limited flow rates, and rely on high filter areas. The latter causes a high volume of extractables and leachables while being unsustainable and causing extortionate financing and running costs.

DrM’s CONTIBAC® single-use filter overcomes such restrictions, using a cyclic cake filtration method, which gives the product’s filter unmatched speed without decreasing filtrate quality. The cyclic operation also allows filtering of the same batch volume with a smaller filter.

Using a small filter is more sustainable and significantly reduces contamination risk. Therefore, CONTIBAC® is advantageous regardless of whether a batch or continuous bioreactor is employed.

Cell culture bioprocessing

Bioprocessing of cell cultures can be divided into three consecutive steps: fermentation, harvesting and purification. Single-use filters are optimum for cell harvesting, suited for cell densities up to 50m cells / ml.

DrM’s single-use filters are complete with a multi-cycle function, enabling smaller footprints and validation and operation cost in comparison to centrifugal and depth filters.

Single-use mixers for cell homogenisation

Liquid batches filled into vials for injection must go through an effective mixing process. The heel must be disposed of promptly, as mixing cannot be guaranteed as the batch is processed and the tank drained. A mixing device that reduces this heel allows higher yields, reducing operating cost.

FUNDAMIX® single-use mixers can move large quantities of liquid without affecting sensitive proteins. Vibrations produce high degrees of random distribution at low shear effects on proteins and without baffles.

Single-use portfolio

As well as filters and mixers, DrM’s product portfolio includes a newly patented pinch valve with a hose size adaptable bed to guarantee uninterrupted operation for many cycles.

The company also developed a control panel system to allow for efficient and automatic use of its own products, as well as those of other companies.

Extended product portfolio

DrM’s non-single-use products for the life sciences industry include its FUNDABAC® technology targeted to companies that adhere to good manufacturing practice (GMP).

STERIBAC® candle filter as a unique execution of the conventional and the traditional FUNDAMIX® vibromixer also make up DrM’s extensive portfolio.

Cell Harvest Using Only One Filter Per Batch

As the biologics industry is moving towards more diverse batch volumes and cell concentrations that are cultivated in single-use facilities, there has been a demand for innovative cell separation technologies.

DrM at ACHEMA 2022: 22 – 26 August, Frankfurt am Main

Modern, interactive and always up to date: With a unique range of topics, exciting focal topics and new event formats, the world's leading trade show for the process industries brings together experts, decision makers and trendsetters from all over the world.

12 May 2022

DrM, Dr. Mueller AG

Alte Landstrasse 415
8708 Maennedorf
Switzerland

DrM Shanghai Co Ltd

Building 2
No 18 Rong Xin Road
Xinqiao, Song Jiang District
Shanghai 201612
China

DrM Polska Sp z oo

Al. Kazimierza Wielkiego 5
PL87-800
Wloclawek
Poland

DrM Filter Technology Private Ltd

501 The Park
O P Road
Near Akshar Chowk
Vadodara
Gujarat 390 020
India

DrM Inc

2125 Center Ave
Suite 507
Fort Lee NJ 07024
United States of America

DrM, Dr Mueller Ltd

Swiss Tower, 20th Floor
PO Box 392394
Dubai
United Arab Emirates

SL Engineering

SEA Regional Office
21 (2nd Floor),
Jalan PCR 1
Kawasan Perniagaan Cheras Raya Batu 11
Selangor 43200
Jalan Balakong Cheras
Malaysia

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