Apitegromab is under clinical development by Scholar Rock and currently in Phase II for Obesity. According to GlobalData, Phase II drugs for Obesity have a 29% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Apitegromab’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Apitegromab overview

Apitegromab (SRK-015) is under development for the treatment of type 2 and type 3 spinal muscular atrophy (SMA) and obesity. It is administered through Intravenous route. The drug candidate is a niche modulator inhibiting activation of the latent myostatin precursor. It was under development for the treatment of Becker muscular dystrophy and other muscle wasting disorders (additional myostatin related disorders).

Scholar Rock overview

Scholar Rock, a subsidiary of Scholar Rock Holding Corp, is a biopharmaceutical company that focuses on the discovery, development and delivery of life-changing therapies for serious diseases with high unmet needs. The company’s main activities involve harnessing cutting-edge science to create new possibilities for patients, with a particular emphasis on targeting growth factors in their inactive precursor forms to selectively regulate their activity. The company’s products include Apitegromab for Spinal Muscular Atrophy and Cardiometabolic Disorders, SRK-439 for novel antimyostatin antibody, SRK-181 for Immuno-Oncology and selective context-dependent treatments for Fibrosis and Anemia. Scholar Rock is headquartered in Cambridge, Massachusetts, the US.

For a complete picture of Apitegromab’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 10 June 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.