ARX-517 is under clinical development by Ambrx Biopharma and currently in Phase II for Ovarian Cancer. According to GlobalData, Phase II drugs for Ovarian Cancer have a 26% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how ARX-517’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

ARX-517 overview

ARX-517 is under development for the treatment of solid tumors including metastatic castration-resistant prostate cancer, pancreatic cancer, non-small lung cancer, ovarian cancer and glioblastoma multiforme. It is administered intravenously. It is an antibody drug conjugate (ADC) targeting prostate specific membrane antigen (PSMA). The drug candidate is based on site-specific conjugation technology using EuCODE mammalian host system and Ambrx technology.

Ambrx Biopharma overview

Ambrx Biopharma (Ambrx) is a clinical stage biopharmaceutical company that develops anti-body drug conjugates (ADC) and therapies to modulate immune system. The company is developing ARX 788, an anti-HER2 ADC for treatment in areas of breast cancer, gastric cancer, and other solid tumors. Its pipeline product also includes ARX 517 program that targets prostate-specific membrane antigen to treat prostate cancer; and ARX305 for treatment of renal cell carcinoma (RCC), nasopharyngeal cancers, multiple myeloma, non-Hodgkin’s lymphoma, and acute myeloid leukemia (AML). Ambrx works in collaboration with Zhejiang Medicine, Sino Biopharmaceutical, and BeiGene. The company is conducting its ADCs clinical trials in China, and the US. Ambrx is headquartered in La Jolla, California, the US.

For a complete picture of ARX-517’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 7 February 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.