Atogepant is a Small Molecule owned by AbbVie, and is involved in 27 clinical trials, of which 21 were completed, 4 are ongoing, and 2 are planned.

Atogepant (MK-8031, AGN-241689) acts as calcitonin gene related peptide receptor antagonist. CGRP is a potent vasodilator, particularly in the cerebral circulation. The release of CGRP within the trigeminal nucleus caudalis facilitates activation of nociceptive second-order neurons and glial cells. The drug candidate by antagonizing CGRP receptor exhibits the analgesic activity.

The revenue for Atogepant is expected to reach a total of $15.1bn through 2038. This change impacts the valuation of this asset and is an important factor to understand the current value of the drug in a clinical process. View the complete picture with the Atogepant NPV Report.

Atogepant was originated by Merck & Co and is currently owned by AbbVie.

Atogepant Overview

Atogepant (Qulipta) is an anti-migraine agent. It is formulated as tablets for oral route of administartion. Qulipta is indicated for the preventive treatment of episodic migraine in adults.

Atogepant (MK-8031, AGN-241689) is under development for the prevention of an episodic and chronic migraine. The drug candidate is administered by oral route as tablet and capsule. It acts by targeting calcitonin gene-related peptide (CGRP) receptor.

AbbVie Overview

AbbVie is a specialty biopharmaceutical company, which discovers, develops, manufactures, and commercializes drugs for the treatment of chronic and complex diseases. Its drugs are indicated for the treatment of metabolic diseases, rheumatological diseases, neurological disorders, viral diseases, skin diseases, complications associated with cystic fibrosis, pain related to endometriosis, diseases of the gastrointestinal tract, various types of cancer, and other serious health conditions. AbbVie is also advancing its pipeline programs for the treatment of cystic fibrosis, women’s health, various cancers, neurological disorders and other autoimmune diseases. The company markets its products directly to wholesalers, distributors, health care facilities, government agencies, specialty pharmacies and independent retailers through its own distribution centers and public warehouses worldwide. AbbVie is headquartered in North Chicago, Illinois, the US.

The company reported revenues of (US Dollars) US$56,197 million for the fiscal year ended December 2021 (FY2021), an increase of 22.7% over FY2020. In FY2021, the company’s operating margin was 31.9%, compared to an operating margin of 24.8% in FY2020. In FY2021, the company recorded a net margin of 20.5%, compared to a net margin of 10.1% in FY2020. The company reported revenues of US$14,812 million for the third quarter ended September 2022, an increase of 1.6% over the previous quarter.

Quick View – Atogepant

Report Segments
  • Innovator (NME)
Drug Name
  • Atogepant
Administration Pathway
  • Oral
Therapeutic Areas
  • Central Nervous System
Key Companies
  • Sponsor Company: AbbVie
  • Originator: Merck & Co
Highest Development Stage
  • Marketed

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, potential applicable patients, drug margins, company expenses, and pricing estimates. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.

The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate rNPV, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA)and phase transition success rate(PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.