Ayala Pharmaceuticals has been granted a patent for recombinant fusion polypeptides containing antigenic peptides from cancer-associated proteins, including recurrent and heteroclitic mutations. The patent covers methods of generating these fusion polypeptides, as well as immunogenic compositions and vaccines for inducing anti-tumor immune responses and treating cancer. GlobalData’s report on Ayala Pharmaceuticals gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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Data Insights Ayala Pharmaceuticals Inc. - Company Profile

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According to GlobalData’s company profile on Ayala Pharmaceuticals, Personalized cancer vaccines was a key innovation area identified from patents. Ayala Pharmaceuticals's grant share as of April 2024 was 15%. Grant share is based on the ratio of number of grants to total number of patents.

Recombinant fusion polypeptides for cancer immunotherapy

Source: United States Patent and Trademark Office (USPTO). Credit: Ayala Pharmaceuticals Inc.

A recently granted patent (Publication Number: US11897927B2) discloses a novel recombinant Listeria strain designed to induce an immune response against cancer. The strain contains a nucleic acid encoding a fusion polypeptide with a PEST-containing peptide fused to two or more antigenic peptides, including those from cancer-associated proteins with recurrent or heteroclitic mutations. The fusion polypeptide also includes a ubiquitin protein and a carboxy-terminal antigenic peptide, arranged in tandem from the amino-terminal end to the carboxy-terminal end. The antigenic peptides encompass mutations from various cancer-related genes, such as SPOP, CHEK2, RGPD8, ANKRD36C, and AR, or CEACAM5, MAGEA4, STEAP1, RNF43, SSX2, SART3, PAGE4, PSMA, and PSA, among others.

Furthermore, the patent claims cover various aspects of the recombinant Listeria strain, including the length and composition of the antigenic peptides, the presence of peptide linkers, and the specific mutations targeted. The patent also extends to immunogenic compositions comprising the recombinant Listeria strain, methods of inducing immune responses against tumors or cancer in subjects, and the creation of a cell bank containing the recombinant Listeria strains. The innovative approach outlined in the patent aims to leverage the unique properties of Listeria to develop effective immunotherapies for cancer treatment, potentially offering new avenues for personalized medicine and targeted therapies in the future.

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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies