AZD-0486 is under clinical development by AstraZeneca and currently in Phase I for B-Cell Non-Hodgkin Lymphoma. According to GlobalData, Phase I drugs for B-Cell Non-Hodgkin Lymphoma have a 75% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how AZD-0486’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
AZD-0486 is under development for the treatment of B-cell non-Hodgkin’s lymphomas including high grade B cell lymphoma, diffuse large B cell lymphoma, follicular lymphoma and B-cell acute lymphoblastic leukemia. The therapeutic candidates are Bi-specific T-cell engager (BiTE) human heavy chain antibodies. They act by targeting immune checkpoint inhibitors. The drug candidates are developed based on high-affinity UniDab molecules from uniRat technology. UniRat is a transgenic rat that uses human immunoglobulin heavy-chain translocus to express a diverse repertoire of human heavy chain antibodies. It is administered through intravenous route.
It was also under development for the treatment of mantle cell lymphoma, marginal zone lymphoma (MZL) and B-cell leukemia.
AstraZeneca is a biopharmaceutical company, which is focused on discovery, production and commercialization of a range of prescription drugs. It develops products related to therapy areas such as respiratory, cardiovascular, renal and metabolic diseases, cancer, autoimmune, infection and neurological diseases. The company’s product portfolio includes biologics, prescription pharmaceuticals and vaccines. AstraZeneca sells its products through wholly- owned local marketing companies, distributors and local representative offices. The company markets its products to primary care and specialty care physicians. The company operates in Europe, the Americas, Asia, Africa and Australasia. AstraZeneca is headquartered in Cambridge, Cambridgeshire, the UK.
For a complete picture of AZD-0486’s drug-specific PTSR and LoA scores, buy the report here.