AZD-4573 is under clinical development by AstraZeneca and currently in Phase I for Relapsed Chronic Lymphocytic Leukemia (CLL). According to GlobalData, Phase I drugs for Relapsed Chronic Lymphocytic Leukemia (CLL) have a 75% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how AZD-4573’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

AZD-4573 overview

AZD-4573 is under development for the treatment of relapsed or refractory hematological malignancies such as diffuse large B-cell lymphoma, B-cell non-Hodgkin lymphoma, T-cell non-Hodgkin lymphoma, small lymphocytic lymphoma, multiple myeloma, chronic lymphocytic leukemia (CLL), relapsed, refractory peripheral T-cell lymphoma, marginal zone b-cell lymphoma, mantle cell lymphoma, follicular lymphoma, classical Hodgkin’s lymphoma, Richter's syndrome, AML/secondary AML, acute lymphocytic leukemia (ALL), high-risk myelodysplastic syndrome (MDS) and chronic myelomonocytic leukemia (CMML). It is administered by intravenous route and acts by targeting cyclin-dependent kinase 9 (CDK9). It is a new molecular entity.

AstraZeneca overview

AstraZeneca is a biopharmaceutical company, which is focused on discovery, production and commercialization of a range of prescription drugs. It develops products related to therapy areas such as respiratory, cardiovascular, renal and metabolic diseases, cancer, autoimmune, infection and neurological diseases. The company’s product portfolio includes biologics, prescription pharmaceuticals and vaccines. AstraZeneca sells its products through wholly-owned local marketing companies, distributors and local representative offices. The company markets its products to primary care and specialty care physicians. The COVID-19 Vaccine AstraZeneca has been approved for conditional marketing or emergency use. The company operates in Europe, the Americas, Asia, Africa and Australasia. AstraZeneca is headquartered in Cambridge, Cambridgeshire, the UK.

For a complete picture of AZD-4573’s drug-specific PTSR and LoA scores, buy the report here.

GlobalData

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.