Belrestotug is a monoclonal antibody commercialized by iTeos Therapeutics, with a leading Phase II program in Relapsed Multiple Myeloma. According to Globaldata, it is involved in 7 clinical trials, of which 1 was completed, and 6 are ongoing. GlobalData uses proprietary data and analytics to provide a complete picture of Belrestotug’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.

The revenue for Belrestotug is expected to reach an annual total of $211 mn by 2038 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.

Belrestotug Overview

EOS-448 is under development for the treatment of solid tumors, non-small cell lung cancer, squamous non-small cell lung cancer, relapsed or refractory multiple myeloma, PD-1 resistant melanoma and head and neck cancer squamous cell carcinoma. It is administered through intravenous route. The drug candidate is a checkpoint blocking antibody acts by targeting TIGIT.

iTeos Therapeutics Overview

iTeos Therapeutics is a clinical-stage biopharmaceutical company. It discovers and develops immuno-oncology drugs for cancer. The company’s major pipeline products are EOS-448, EOS-984, dostarlimab, iberdomide, pembrolizumab, CD96 drug candidates. Its products are used to treat various cancers like advanced malignancies, relapsed refractory multiple myeloma. The drug candidates either in monotherapy or in combination with additional drugs, as well as in intraportfolio combinations. Its service includes to carries out clinical trials for inupadenant, an A2A receptor antagonist, as a treatment for solid tumors in monotherapy. It has operational presence in the US; and Belgium. iTeos Therapeutics is headquartered in Cambridge, Massachusetts, the US.

The company reported revenues of (US Dollars) US$267.6 million for the fiscal year ended December 2022 (FY2022), a decrease of 22.4% over FY2021. In FY2022, the company’s operating margin was 47.2%, compared to an operating margin of 71% in FY2021. In FY2022, the company recorded a net margin of 36.1%, compared to a net margin of 62.2% in FY2021. The company reported revenues of US$12.6 million for the first quarter ended March 2023, a decrease of 76.6% over the previous quarter.

For a complete picture of Belrestotug’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.

This content was updated on 2 September 2023

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.

The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.