Bexotegrast is a small molecule commercialized by Pliant Therapeutics, with a leading Phase III program in Idiopathic Pulmonary Fibrosis. According to Globaldata, it is involved in 11 clinical trials, of which 7 were completed, 3 are ongoing, and 1 was terminated. GlobalData uses proprietary data and analytics to provide a complete picture of Bexotegrast’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.

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The revenue for Bexotegrast is expected to reach an annual total of $464 mn by 2037 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.

Bexotegrast Overview

Bexotegrast (PLN-74809) is under development for the treatment of primary sclerosing cholangitis, idiopathic pulmonary fibrosis (IPF), liver fibrosis and COVID-19-related acute respiratory distress syndrome. The drug candidate acts by targeting integrin alpha 5 beta 6 and integrin alpha 5 beta 1.

Pliant Therapeutics Overview

Pliant Therapeutics is a clinical-stage biopharmaceutical company that discovers and develops novel therapies for the treatment of fibrosis. The company’s pipeline products include PLN-74809, PLN-101095, PLN-101325 and PLN-1474. Its pipeline candidates treat idiopathic pulmonary fibrosis (IPF), primary sclerosing cholangitis (PSC), solid tumors, other muscular dystrophies and NASH-associated liver fibrosis. The company is also evaluating therapies to treat muscular dystrophy, solid tumors, and cancer. It works in partnership with Novartis AG and other institutions, universities, medical centers, physicians and researchers to develop its products. Pliant Therapeutics is headquartered in South San Francisco, California, the US.
The company reported revenues of (US Dollars) US$9.7 million for the fiscal year ended December 2022 (FY2022), an increase of 27.9% over FY2021. The operating loss of the company was US$127.2 million in FY2022, compared to an operating loss of US$97.5 million in FY2021. The net loss of the company was US$123.3 million in FY2022, compared to a net loss of US$97.3 million in FY2021.

For a complete picture of Bexotegrast’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.

This content was updated on 24 July 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.

The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.