BioGaia has filed a patent for a method to enhance probiotic L. reuteri strains’ survival and activity in mammals by pre-conditioning with GOS during cultivation. The method involves growing the bacteria in a medium containing GOS and administering the pre-conditioned bacteria with additional GOS for symbiotic benefits in the gastrointestinal tract. GlobalData’s report on BioGaia gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on BioGaia, Lactobacillus probiotics was a key innovation area identified from patents. BioGaia's grant share as of January 2024 was 45%. Grant share is based on the ratio of number of grants to total number of patents.

Probiotic composition preparation method using gos for l. reuteri

Source: United States Patent and Trademark Office (USPTO). Credit: BioGaia AB

A patent application (Publication Number: US20230405062A1) discloses a method for preparing a probiotic composition involving the pre-conditioning of a probiotic Lactobacillus reuteri strain by cultivating it in the presence of galacto-oligosaccharide (GOS) in a growth medium. The pre-conditioned strain is then harvested and combined with GOS to create the probiotic composition. The amount of GOS added during cultivation ranges from 0.2 wt % to 8 wt %, and during the preparation of the composition, it is added in an amount of at least 1 g, or between 2 to 12 g. The probiotic composition includes various strains of L. reuteri and can be in different forms such as powder, tablet, capsule, or emulsion, suitable for administration as a nutritional composition, pharmaceutical formulation, dietary supplement, functional food product, or functional beverage product.

Furthermore, the patent application describes the use of the probiotic composition for various health benefits, including improving mineral bio-accessibility, promoting a healthy microbiota, enhancing the survival of L. reuteri in the colon, increasing metabolic activity of gut microbiota, promoting bone health, and treating conditions like mineral deficiencies, digestive dysfunctions, dysbiosis, bone loss, infections, and promoting growth and development of bones or teeth in children. The methods involve administering the probiotic composition to individuals in need of such health benefits, with specific applications for treating iron deficiency anemia, gut infections, and promoting overall gut health. The composition can be particularly useful in preventing and managing a range of health conditions related to gut health, bone health, and overall well-being.

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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies