Bisantrene hydrochloride is under clinical development by Race Oncology and currently in Phase II for Chronic Myelomonocytic Leukemia (CMML). According to GlobalData, Phase II drugs for Chronic Myelomonocytic Leukemia (CMML) have a 48% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Bisantrene hydrochloride’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Bisantrene hydrochloride overview

Bisantrene hydrochloride (UPI-928) is under development for the treatment of adult and pediatric relapsed and refractory acute myelogenous leukemia, permanent heart damage caused by the chemotherapeutic anthracycline doxorubicin, myelodysplastic syndrome, CMML, breast cancer, ovarian cancer. The drug candidate is a small molecule anthracene derivative. It acts by targeting FTO. It is administered through intravenous route.

Race Oncology overview

Race Oncology, formerly Coronado Resources, discovers and develops novel RNA (ribonucleic acid) directed drugs to treat cancer. The company is investigating Zantrene, a potent small molecule inhibitor of fat mass and obesity associated (FTO) protein for relapsed and refractory acute myeloid leukemia (r/r AML), extramedullary disease (EMD) AML, myelodysplastic syndrome (MDS), and breast cancer. It is also evaluating Zantrene against solid tumors, melanoma, clear cell renal cell carcinoma, and lung cancer. The company’s product candidate acts as an anthracycline-like chemotherapeutic causing less cardiotoxicity (heart damage) in cancer patients. Race Oncology is headquartered in Sydney, New South Wales, Australia.

For a complete picture of Bisantrene hydrochloride’s drug-specific PTSR and LoA scores, buy the report here.


GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.