Bortezomib is a Small Molecule owned by Millennium Pharmaceuticals, and is involved in 254 clinical trials, of which 212 were completed, 41 are ongoing, and 1 is planned.

Bortezomib reversibly inhibits the 26S proteasome, a large protease complex that degrades ubiquinated proteins. By blocking the targeted proteolysis normally performed by the proteasome, bortezomib disrupts various cell signaling pathways, leading to cell cycle arrest, apoptosis, and inhibition of angiogenesis. Specifically, the agent inhibits nuclear factor (NF)-kappaB, a protein that is constitutively activated in some cancers, thereby interfering with NF-kappaB-mediated cell survival, tumor growth, and angiogenesis.

The revenue for Bortezomib is expected to reach a total of $1.1bn through 2038. This change impacts the valuation of this asset and is an important factor to understand the current value of the drug in a clinical process. View the complete picture with the Bortezomib NPV Report.

Bortezomib was originated by ProScript and is currently owned by Millennium Pharmaceuticals. Takeda Pharmaceutical is the other company associated in development or marketing of Bortezomib.

Bortezomib Overview

Bortezomib (Velcade) is a dipeptide boronic acid analogue with anti-neoplastic activity. It is formulated as lyophilized powder for solution for intravenous or subcutaneous route of administration. Velcade is indicated for the treatment of multiple myeloma. The drug candidate is under development for the treatment of non-small cell lung cancer, diffuse large B-cell lymphoma, graft versus host disease, relapsed or refractory acute myelogenous leukemia, primary plasma cell leukemia, acute lymphoblastic leukemia and myelodysplastic syndrome. The drug candidate was also under development for the treatment of B-cell lymphomas including marginal zone B-cell lymphoma, nodal marginal zone B-cell lymphoma, extranodal marginal zone B-cell lymphoma, splenic marginal zone B-cell lymphoma and follicular lymphoma, as first line therapy for non-cutaneous peripheral T-cell lymphoma, including human T-cell lymphotropic virus type 1 (HTLV-1) related T-cell lymphoma, and natural killer (NK)-cell lymphoma, epithelial ovarian cancer, primary peritoneal cancer and fallopian tube cancer, relapsed/refractory light chain amyloidosis, metastatic colorectal carcinoma, follicular non-Hodgkin lymphoma, peripheral T-cell lymphoma, cutaneous T-cell lymphoma, metastatic ductal adenocarcinoma of the pancreas, bronchioloalveolar carcinoma, metastatic breast cancer, myasthenia gravis, systemic lupus erythematosus, rheumatoid arthritis, Waldenstrom macroglobulinemia and adenocarcinoma with bronchioloalveolar features.

Takeda Pharmaceutical Overview

Takeda Pharmaceutical (Takeda) is a research-based pharmaceutical company which focuses on the discovery, development, manufacturing, marketing, commercialization, import and export of pharmaceutical drugs. The company offers products in the areas of rare diseases, gastrointestinal, oncology, neuroscience, vaccines, and plasma-derived therapies. Takeda has facilities in Japan, Argentina, Brazil, Mexico, the US, Denmark, Norway, Europe, Poland, Russia, Spain, Switzerland, China and India, Canada among others. It markets products directly and through a network of wholesale distributors, retail chains and other purchasing groups worldwide. Takeda has partnership with academic institutions, small biotech, and large pharmaceutical companies. It has presence in the Americas, Europe, and Asia, among others. Takeda is headquartered in Tokyo, Japan.

The company reported revenues of (Yen) JPY3,569,006 million for the fiscal year ended March 2022 (FY2022), an increase of 11.6% over FY2021. In FY2022, the company’s operating margin was 12.5%, compared to an operating margin of 18.8% in FY2021. In FY2022, the company recorded a net margin of 6.4%, compared to a net margin of 11.8% in FY2021. The company reported revenues of JPY1,002,307 million for the second quarter ended September 2022, an increase of 3.1% over the previous quarter.

Quick View – Bortezomib

Report Segments
  • Innovator (NME)
Drug Name
  • Bortezomib
Administration Pathway
  • Intravenous
  • Subcutaneous
Therapeutic Areas
  • Immunology
  • Metabolic Disorders
  • Oncology
Key Companies
Highest Development Stage
  • Marketed

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, potential applicable patients, drug margins, company expenses, and pricing estimates. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.

The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate rNPV, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA)and phase transition success rate(PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.