CDX-1140 is under clinical development by Celldex Therapeutics and currently in Phase II for Endometrial Cancer. According to GlobalData, Phase II drugs for Endometrial Cancer have a 22% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how CDX-1140’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
CDX-1140 overview
CDX-1140 is under development for the treatment of metastatic biliary tract cancer, epithelial ovarian cancer, fallopian tube cancer, peritoneal cancer, endometrial cancer and triple negative breast cancer. It is administered through intravenous route. The drug candidates acts by targeting B-cell surface antigen CD40.
The drug candidate was under development for the treatment of lymphoma like advanced diffuse large B-cell lymphoma (DLBCL), metastatic pancreatic adenocarcinoma pancreatic ductal adenocarcinoma, mantle cell lymphoma, or indolent B-cell lymphoma, metastatic melanoma, solid tumor, bladder cancer, urothelial cancer, follicular lymphoma, non-small cell lung cancer, breast cancer, colorectal cancer, gastric cancer, esophageal cancer, renal cell cancer, hepatic cancer, ovarian cancer, head and neck cancer, bile duct cancer.
Celldex Therapeutics overview
Celldex Therapeutics (Celldex) is a bio-pharmaceutical company that discovers, develops, and commercializes targeted immunotherapy and other biologics for the treatment of various types of cancers. The company’s developmental pipeline comprises therapeutic antibodies, antibody drug conjugates (ADCs), protein-based therapeutics, immune system modulators and vaccine for unmet medical needs. Its key products in development include CDX-1140; CDX-527, CDX-0159. It’s products find application in the treatment of various indications such as brain cancer, triple negative breast cancer, lymphoma/leukemia, melanoma, and renal cell carcinoma. It operates a manufacturing facility in Massachusetts, the US, and research laboratories in Massachusetts, New Jersey, and Connecticut. Celldex is headquartered in Hampton, New Jersey, the US.
For a complete picture of CDX-1140’s drug-specific PTSR and LoA scores, buy the report here.
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