Chemomab Therapeutics has been granted a patent for a pharmaceutical composition that includes isolated anti-CCL24 (eotaxin 2) antibodies. This composition is designed for the treatment of intrahepatic cholestatic liver diseases, featuring a fully humanized antibody with specific sequence homologies. GlobalData’s report on Chemomab Therapeutics gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Chemomab Therapeutics, Human telomerase RT biomarker was a key innovation area identified from patents. Chemomab Therapeutics's grant share as of June 2024 was 45%. Grant share is based on the ratio of number of grants to total number of patents.
Anti ccl24 antibodies for treating hepatic pathologies
The granted patent US12018074B2 outlines a pharmaceutical composition specifically designed for the treatment of hepatic pathologies, particularly intrahepatic cholestatic liver diseases. Central to this composition is an isolated anti-CCL24 (eotaxin 2) antibody, or its antigen-binding fragments, which is characterized as a fully humanized antibody. This antibody includes six complementarity-determining regions (CDRs) as specified by SEQ ID Nos 1-6, along with a heavy chain variable region that exhibits at least 90% sequence homology to SEQ ID NO:7 and a light chain variable region with at least 90% sequence homology to SEQ ID NO:8. The patent emphasizes the application of this composition in treating conditions such as primary sclerosing cholangitis (PSC), primary biliary cirrhosis (PBC), and cholangiocarcinoma resulting from PSC.
Additionally, the claims specify that the pharmaceutical composition may include at least one additional therapeutic agent, enhancing its potential efficacy in treating the specified hepatic diseases. The detailed structure of the antibody, including its humanized nature and specific sequence homologies, underscores the innovative approach taken in developing this treatment. The patent thus presents a targeted therapeutic strategy aimed at addressing significant liver diseases, which could have implications for patient care in hepatology.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
