Claudiximab is a monoclonal antibody commercialized by Astellas Pharma, with a leading Phase II program in Metastatic Adenocarcinoma of The Pancreas. According to Globaldata, it is involved in 11 clinical trials, of which 8 were completed, and 3 are ongoing. GlobalData uses proprietary data and analytics to provide a complete picture of Claudiximab’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.

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The revenue for Claudiximab is expected to reach an annual total of $28 mn by 2036 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.

Claudiximab Overview

Zolbetuximab (claudiximab, IMAB-362) is under development for the treatment of advanced adenocarcinoma of the Gastroesophageal Junction, gastric cancer and metastatic pancreatic adenocarcinoma. The drug candidate is administered as an intravenous infusion. It is an Ig1 iMAB acts by targeting splice variant of claudin 18 target (claudin 18.2). It is developed based on ideal monoclonal antibody (IMABS) therapeutics. It was under development for the treatment of solid tumors including ovarian cancer and lung cancer.

Astellas Pharma Overview

Astellas Pharma (Astellas) discovers, develops, manufactures, and commercializes a wide range of pharmaceuticals. The company’s product portfolio comprises marketed products for the treatment of a wide range of urological diseases, cancer, nephrology, infectious diseases, and metabolic diseases, immunodeficiency, and transplantation. The company strives to develop new drugs to address high unmet medical needs with focus on biology and modality. Its pipeline consists of drug candidates for the treatment of urothelial cancer; gastric cancer; gastroesophageal junction cancer; anemia associated with chronic kidney disease (CKD) in dialysis; and acute myeloid leukemia (AML), among others. It operates in the Americas, Australia, Europe, and Asia and Oceania through a network of subsidiaries and affiliates. Astellas is headquartered in Chuo-Ku, Tokyo, Japan.

The company reported revenues of (Yen) JPY1,518,619 million for the fiscal year ended March 2023 (FY2023), an increase of 17.2% over FY2022. In FY2023, the company’s operating margin was 8.4%, compared to an operating margin of 12.4% in FY2022. In FY2023, the company recorded a net margin of 6.5%, compared to a net margin of 9.6% in FY2022. The company reported revenues of JPY392,147 million for the second quarter ended September 2023, an increase of 4.6% over the previous quarter.

For a complete picture of Claudiximab’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.

This content was updated on 7 February 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.

The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.